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Use of RNA-Seq and a Transgenic Mouse Model to Identify Genes Which May Contribute to Mutant p53-Driven Prostate Cancer Initiation

SIMPLE SUMMARY: We use RNA-seq analysis to identify genes that may contribute to mutant p53-mediated prostate cancer initiation in a genetically engineered mouse model (B6.129S4-Trp53tm3.1Tyj/J). A total of 1378 differentially expressed genes, including wildtype p53 target genes (e.g. Cdkn1a, Bax, B...

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Detalles Bibliográficos
Autores principales:	Vinall, Ruth, Chen, Qian, Talbott, George, Ramsamooj, Rajendra, Dang, An, Tepper, Clifford G., Borowsky, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869245/ https://www.ncbi.nlm.nih.gov/pubmed/35205085 http://dx.doi.org/10.3390/biology11020218

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