Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis

SIMPLE SUMMARY: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the motor neurons in the brain and spinal cord. Mutations in the gene Matr3 have been linked to ALS, including the autosomal dominant missense mutation S85C. We previously created a mouse model containing th...

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Detalles Bibliográficos
Autores principales: You, Justin, Maksimovic, Katarina, Lee, Jooyun, Khan, Mashiat, Masuda, Rintaro, Park, Jeehye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869279/
https://www.ncbi.nlm.nih.gov/pubmed/35205163
http://dx.doi.org/10.3390/biology11020298

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