Cargando…

CCN2 Binds to Tubular Epithelial Cells in the Kidney

Cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), is considered a fibrotic biomarker and has been suggested as a potential therapeutic target for kidney pathologies. CCN2 is a matricellular protein with four distinct structural modules that can exert a dual...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rayego-Mateos, Sandra, Morgado-Pascual, José Luis, Lavoz, Carolina, Rodrigues-Díez, Raúl R., Márquez-Expósito, Laura, Tejera-Muñoz, Antonio, Tejedor-Santamaría, Lucía, Rubio-Soto, Irene, Marchant, Vanessa, Ruiz-Ortega, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869303/ https://www.ncbi.nlm.nih.gov/pubmed/35204752 http://dx.doi.org/10.3390/biom12020252

Ejemplares similares

CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation
por: Tejera-Muñoz, Antonio, et al.
Publicado: (2021)

Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney
por: Marquez-Exposito, Laura, et al.
Publicado: (2022)

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis
por: Marquez-Exposito, Laura, et al.
Publicado: (2018)

Statins: Could an old friend help in the fight against COVID‐19?
por: Rodrigues‐Diez, Raul R., et al.
Publicado: (2020)

Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
por: Tejedor-Santamaria, Lucia, et al.
Publicado: (2022)

Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy?
por: Lavoz, Carolina, et al.
Publicado: (2020)

CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation
por: Rayego-Mateos, Sandra, et al.
Publicado: (2023)

Special Issue “Diabetic Nephropathy: Diagnosis, Prevention and Treatment”
por: Ruiz-Ortega, Marta, et al.
Publicado: (2020)

Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes
por: Marquez-Exposito, Laura, et al.
Publicado: (2021)

Role of Macrophages and Related Cytokines in Kidney Disease
por: Cantero-Navarro, Elena, et al.
Publicado: (2021)

IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis
por: Marchant, Vanessa, et al.
Publicado: (2020)

Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology
por: Morgado-Pascual, Jose Luis, et al.
Publicado: (2018)

TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2
por: Rodrigues-Díez, Raquel, et al.
Publicado: (2015)

Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-β-Independent Process
por: Rodrigues Díez, Raúl, et al.
Publicado: (2010)

Angiotensin II Contributes to Renal Fibrosis Independently of Notch Pathway Activation
por: Lavoz, Carolina, et al.
Publicado: (2012)

Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells
por: Morgado-Pascual, Jose L., et al.
Publicado: (2015)

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases
por: Morgado-Pascual, Jose Luis, et al.
Publicado: (2019)

Vitamin D, Cellular Senescence and Chronic Kidney Diseases: What Is Missing in the Equation?
por: Martinelli, Romina P., et al.
Publicado: (2023)

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage
por: Rayego-Mateos, Sandra, et al.
Publicado: (2018)

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells
por: Rodrigues-Diez, Raquel, et al.
Publicado: (2014)

The CCN2 Polymorphism rs12526196 Is a Risk Factor for Ascending Thoracic Aortic Aneurysm
por: Tejera-Muñoz, Antonio, et al.
Publicado: (2022)

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice
por: Opazo-Ríos, Lucas, et al.
Publicado: (2022)

Molecular Mechanisms of Kidney Injury and Repair
por: Rayego-Mateos, Sandra, et al.
Publicado: (2022)

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury
por: Valentijn, Floris A., et al.
Publicado: (2021)

Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis
por: Morgado-Pascual, José Luis, et al.
Publicado: (2022)

VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy
por: Lavoz, Carolina, et al.
Publicado: (2020)

Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
por: Priego, Alberto Ruiz, et al.
Publicado: (2021)

BET Protein Inhibitor JQ1 Modulates Mitochondrial Dysfunction and Oxidative Stress Induced by Chronic Kidney Disease
por: Rayego-Mateos, Sandra, et al.
Publicado: (2023)

Inflammatory and Fibrotic Mediators in Renal Diseases
por: Rayego-Mateos, Sandra, et al.
Publicado: (2019)

Matricellular CCN proteins
por: Perbal, Bernard
Publicado: (2008)

The skinny on CCN2
por: Leask, Andrew
Publicado: (2008)

New insight into CCN3 interactions - Nuclear CCN3 : fact or fantasy?
por: Perbal, Bernard
Publicado: (2006)

Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2
por: Leask, Andrew
Publicado: (2009)

CCN3 and calcium signaling
por: Lombet, Alain, et al.
Publicado: (2003)

Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration
por: Kubota, Satoshi, et al.
Publicado: (2022)

Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension
por: Orejudo, Macarena, et al.
Publicado: (2019)

Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts
por: Peidl, Alexander, et al.
Publicado: (2019)

Protective role of renal proximal tubular alpha-synuclein in the pathogenesis of kidney fibrosis
por: Bozic, Milica, et al.
Publicado: (2020)

International CCN society and intercellular signaling
por: Perbal, Bernard
Publicado: (2007)

NOV story: the way to CCN3
por: Perbal, Bernard
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_9bv82ojc8ma1lpsnqncer0rr19