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Modeling Alzheimer’s Disease in Caenorhabditis elegans

Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins generate early-onset Alzheimer’s disease (EOA...

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Autores principales: Alvarez, Javier, Alvarez-Illera, Pilar, Santo-Domingo, Jaime, Fonteriz, Rosalba I., Montero, Mayte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869312/
https://www.ncbi.nlm.nih.gov/pubmed/35203497
http://dx.doi.org/10.3390/biomedicines10020288
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author Alvarez, Javier
Alvarez-Illera, Pilar
Santo-Domingo, Jaime
Fonteriz, Rosalba I.
Montero, Mayte
author_facet Alvarez, Javier
Alvarez-Illera, Pilar
Santo-Domingo, Jaime
Fonteriz, Rosalba I.
Montero, Mayte
author_sort Alvarez, Javier
collection PubMed
description Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins generate early-onset Alzheimer’s disease (EOAD), and many other genes modulate the disease in its sporadic form. However, the precise molecular mechanisms underlying AD pathology are still unclear. Because of ethical limitations, we need to use animal models to investigate these processes. The nematode Caenorhabditis elegans has received considerable attention in the last 25 years, since the first AD models overexpressing Aβ peptide were described. We review here the main results obtained using this model to study AD. We include works studying the basic molecular mechanisms of the disease, as well as those searching for new therapeutic targets. Although this model also has important limitations, the ability of this nematode to generate knock-out or overexpression models of any gene, single or combined, and to carry out toxicity, recovery or survival studies in short timeframes with many individuals and at low cost is difficult to overcome. We can predict that its use as a model for various diseases will certainly continue to increase.
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spelling pubmed-88693122022-02-25 Modeling Alzheimer’s Disease in Caenorhabditis elegans Alvarez, Javier Alvarez-Illera, Pilar Santo-Domingo, Jaime Fonteriz, Rosalba I. Montero, Mayte Biomedicines Review Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins generate early-onset Alzheimer’s disease (EOAD), and many other genes modulate the disease in its sporadic form. However, the precise molecular mechanisms underlying AD pathology are still unclear. Because of ethical limitations, we need to use animal models to investigate these processes. The nematode Caenorhabditis elegans has received considerable attention in the last 25 years, since the first AD models overexpressing Aβ peptide were described. We review here the main results obtained using this model to study AD. We include works studying the basic molecular mechanisms of the disease, as well as those searching for new therapeutic targets. Although this model also has important limitations, the ability of this nematode to generate knock-out or overexpression models of any gene, single or combined, and to carry out toxicity, recovery or survival studies in short timeframes with many individuals and at low cost is difficult to overcome. We can predict that its use as a model for various diseases will certainly continue to increase. MDPI 2022-01-26 /pmc/articles/PMC8869312/ /pubmed/35203497 http://dx.doi.org/10.3390/biomedicines10020288 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alvarez, Javier
Alvarez-Illera, Pilar
Santo-Domingo, Jaime
Fonteriz, Rosalba I.
Montero, Mayte
Modeling Alzheimer’s Disease in Caenorhabditis elegans
title Modeling Alzheimer’s Disease in Caenorhabditis elegans
title_full Modeling Alzheimer’s Disease in Caenorhabditis elegans
title_fullStr Modeling Alzheimer’s Disease in Caenorhabditis elegans
title_full_unstemmed Modeling Alzheimer’s Disease in Caenorhabditis elegans
title_short Modeling Alzheimer’s Disease in Caenorhabditis elegans
title_sort modeling alzheimer’s disease in caenorhabditis elegans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869312/
https://www.ncbi.nlm.nih.gov/pubmed/35203497
http://dx.doi.org/10.3390/biomedicines10020288
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