Cargando…

Neuroimaging of Mouse Models of Alzheimer’s Disease

Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular an...

Descripción completa

Detalles Bibliográficos
Autores principales: Jullienne, Amandine, Trinh, Michelle V., Obenaus, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869427/
https://www.ncbi.nlm.nih.gov/pubmed/35203515
http://dx.doi.org/10.3390/biomedicines10020305
_version_ 1784656495298740224
author Jullienne, Amandine
Trinh, Michelle V.
Obenaus, Andre
author_facet Jullienne, Amandine
Trinh, Michelle V.
Obenaus, Andre
author_sort Jullienne, Amandine
collection PubMed
description Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies.
format Online
Article
Text
id pubmed-8869427
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88694272022-02-25 Neuroimaging of Mouse Models of Alzheimer’s Disease Jullienne, Amandine Trinh, Michelle V. Obenaus, Andre Biomedicines Review Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies. MDPI 2022-01-28 /pmc/articles/PMC8869427/ /pubmed/35203515 http://dx.doi.org/10.3390/biomedicines10020305 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jullienne, Amandine
Trinh, Michelle V.
Obenaus, Andre
Neuroimaging of Mouse Models of Alzheimer’s Disease
title Neuroimaging of Mouse Models of Alzheimer’s Disease
title_full Neuroimaging of Mouse Models of Alzheimer’s Disease
title_fullStr Neuroimaging of Mouse Models of Alzheimer’s Disease
title_full_unstemmed Neuroimaging of Mouse Models of Alzheimer’s Disease
title_short Neuroimaging of Mouse Models of Alzheimer’s Disease
title_sort neuroimaging of mouse models of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869427/
https://www.ncbi.nlm.nih.gov/pubmed/35203515
http://dx.doi.org/10.3390/biomedicines10020305
work_keys_str_mv AT jullienneamandine neuroimagingofmousemodelsofalzheimersdisease
AT trinhmichellev neuroimagingofmousemodelsofalzheimersdisease
AT obenausandre neuroimagingofmousemodelsofalzheimersdisease