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Neuroimaging of Mouse Models of Alzheimer’s Disease
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869427/ https://www.ncbi.nlm.nih.gov/pubmed/35203515 http://dx.doi.org/10.3390/biomedicines10020305 |
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author | Jullienne, Amandine Trinh, Michelle V. Obenaus, Andre |
author_facet | Jullienne, Amandine Trinh, Michelle V. Obenaus, Andre |
author_sort | Jullienne, Amandine |
collection | PubMed |
description | Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies. |
format | Online Article Text |
id | pubmed-8869427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88694272022-02-25 Neuroimaging of Mouse Models of Alzheimer’s Disease Jullienne, Amandine Trinh, Michelle V. Obenaus, Andre Biomedicines Review Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies. MDPI 2022-01-28 /pmc/articles/PMC8869427/ /pubmed/35203515 http://dx.doi.org/10.3390/biomedicines10020305 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jullienne, Amandine Trinh, Michelle V. Obenaus, Andre Neuroimaging of Mouse Models of Alzheimer’s Disease |
title | Neuroimaging of Mouse Models of Alzheimer’s Disease |
title_full | Neuroimaging of Mouse Models of Alzheimer’s Disease |
title_fullStr | Neuroimaging of Mouse Models of Alzheimer’s Disease |
title_full_unstemmed | Neuroimaging of Mouse Models of Alzheimer’s Disease |
title_short | Neuroimaging of Mouse Models of Alzheimer’s Disease |
title_sort | neuroimaging of mouse models of alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869427/ https://www.ncbi.nlm.nih.gov/pubmed/35203515 http://dx.doi.org/10.3390/biomedicines10020305 |
work_keys_str_mv | AT jullienneamandine neuroimagingofmousemodelsofalzheimersdisease AT trinhmichellev neuroimagingofmousemodelsofalzheimersdisease AT obenausandre neuroimagingofmousemodelsofalzheimersdisease |