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HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO(.)), positively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly understood. Using isolated perfused rat hea...

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Detalles Bibliográficos
Autores principales:	Mancardi, Daniele, Pagliaro, Pasquale, Ridnour, Lisa A., Tocchetti, Carlo G., Miranda, Katrina, Juhaszova, Magdalena, Sollott, Steven J., Wink, David A., Paolocci, Nazareno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869498/ https://www.ncbi.nlm.nih.gov/pubmed/35204265 http://dx.doi.org/10.3390/antiox11020382

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