Cargando…

The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women

In both sexes, aggression has been described as a critical trait to acquire social status. Still, almost uniquely in men, the link between aggressiveness and the genetic background of testosterone sensitivity measured from the polymorphism in the androgen receptor (AR) gene has been previously inves...

Descripción completa

Detalles Bibliográficos
Autores principales: Valenzuela, Nohelia T., Ruiz-Pérez, Irene, Rodríguez-Sickert, Carlos, Polo, Pablo, Muñoz-Reyes, José Antonio, Yeste-Lizán, Ali, Pita, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869512/
https://www.ncbi.nlm.nih.gov/pubmed/35200293
http://dx.doi.org/10.3390/bs12020042
_version_ 1784656515158769664
author Valenzuela, Nohelia T.
Ruiz-Pérez, Irene
Rodríguez-Sickert, Carlos
Polo, Pablo
Muñoz-Reyes, José Antonio
Yeste-Lizán, Ali
Pita, Miguel
author_facet Valenzuela, Nohelia T.
Ruiz-Pérez, Irene
Rodríguez-Sickert, Carlos
Polo, Pablo
Muñoz-Reyes, José Antonio
Yeste-Lizán, Ali
Pita, Miguel
author_sort Valenzuela, Nohelia T.
collection PubMed
description In both sexes, aggression has been described as a critical trait to acquire social status. Still, almost uniquely in men, the link between aggressiveness and the genetic background of testosterone sensitivity measured from the polymorphism in the androgen receptor (AR) gene has been previously investigated. We assessed the relevance of the AR gene to understand aggression and how aggressiveness affects social status in a cross-sectional study of 195 participants, for the first time in both young men and women. We estimated polymorphism sequences from saliva and measured aggression and self-perceived social status. Unfortunately, the results did not support our prediction because we did not find any of the expected relationships. Therefore, the results suggest that the genetic association between aggressive mechanisms and polymorphism of the AR gene is less straightforward than expected, at least in men, and seems to indicate that aggression is not usually used to gain social status in our population.
format Online
Article
Text
id pubmed-8869512
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88695122022-02-25 The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women Valenzuela, Nohelia T. Ruiz-Pérez, Irene Rodríguez-Sickert, Carlos Polo, Pablo Muñoz-Reyes, José Antonio Yeste-Lizán, Ali Pita, Miguel Behav Sci (Basel) Article In both sexes, aggression has been described as a critical trait to acquire social status. Still, almost uniquely in men, the link between aggressiveness and the genetic background of testosterone sensitivity measured from the polymorphism in the androgen receptor (AR) gene has been previously investigated. We assessed the relevance of the AR gene to understand aggression and how aggressiveness affects social status in a cross-sectional study of 195 participants, for the first time in both young men and women. We estimated polymorphism sequences from saliva and measured aggression and self-perceived social status. Unfortunately, the results did not support our prediction because we did not find any of the expected relationships. Therefore, the results suggest that the genetic association between aggressive mechanisms and polymorphism of the AR gene is less straightforward than expected, at least in men, and seems to indicate that aggression is not usually used to gain social status in our population. MDPI 2022-02-10 /pmc/articles/PMC8869512/ /pubmed/35200293 http://dx.doi.org/10.3390/bs12020042 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valenzuela, Nohelia T.
Ruiz-Pérez, Irene
Rodríguez-Sickert, Carlos
Polo, Pablo
Muñoz-Reyes, José Antonio
Yeste-Lizán, Ali
Pita, Miguel
The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title_full The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title_fullStr The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title_full_unstemmed The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title_short The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women
title_sort relationship between androgen receptor gene polymorphism, aggression and social status in young men and women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869512/
https://www.ncbi.nlm.nih.gov/pubmed/35200293
http://dx.doi.org/10.3390/bs12020042
work_keys_str_mv AT valenzuelanoheliat therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT ruizperezirene therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT rodriguezsickertcarlos therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT polopablo therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT munozreyesjoseantonio therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT yestelizanali therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT pitamiguel therelationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT valenzuelanoheliat relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT ruizperezirene relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT rodriguezsickertcarlos relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT polopablo relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT munozreyesjoseantonio relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT yestelizanali relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen
AT pitamiguel relationshipbetweenandrogenreceptorgenepolymorphismaggressionandsocialstatusinyoungmenandwomen