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Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension
Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869594/ https://www.ncbi.nlm.nih.gov/pubmed/35200304 http://dx.doi.org/10.3390/bs12020053 |
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author | Wallace, Kedra Bowles, Teylor Griffin, Ashley Robinson, Reanna Solis, Lucia Railey, Teryn Shaffery, James P. Araji, Sarah Spencer, Shauna-Kay |
author_facet | Wallace, Kedra Bowles, Teylor Griffin, Ashley Robinson, Reanna Solis, Lucia Railey, Teryn Shaffery, James P. Araji, Sarah Spencer, Shauna-Kay |
author_sort | Wallace, Kedra |
collection | PubMed |
description | Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period. Using preclinical rodent models, we set out to determine whether rats with a history of PreE or HELLP had evidence of anxiety, depression or cognitive impairment and whether immune suppression during pregnancy prevented these changes in mood and/or cognition. Methods: Timed-pregnant rats were infused with sFlt-1 and/or sEng to induce PreE or HELLP beginning on gestational day 12. After delivery, a battery of validated behavioral assays was used to assess post-partum depression, anxiety and learning. Results: There was no negative effect on maternal pup interaction due to PreE or HELLP; however, hypertensive dams spent more time immobile in the forced swim test (p < 0.0001). Hypertensive dams also spent less time in the open area of the open field (p = 0.001). There were no significant changes in recognition memory (p = 0.08); however, spatial learning was impaired in hypertensive dams (p = 0.003). Immobility time in the forced swim test was positively correlated with increased circulating S100B (p = 0.04), while increased time spent in the outer zones of the open field was negatively correlated with BDNF levels (p < 0.0001). Conclusion: The results from this study suggest that hypertensive pregnancy disorders are associated with depression, anxiety and learning impairments in the post-partum period. |
format | Online Article Text |
id | pubmed-8869594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88695942022-02-25 Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension Wallace, Kedra Bowles, Teylor Griffin, Ashley Robinson, Reanna Solis, Lucia Railey, Teryn Shaffery, James P. Araji, Sarah Spencer, Shauna-Kay Behav Sci (Basel) Article Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period. Using preclinical rodent models, we set out to determine whether rats with a history of PreE or HELLP had evidence of anxiety, depression or cognitive impairment and whether immune suppression during pregnancy prevented these changes in mood and/or cognition. Methods: Timed-pregnant rats were infused with sFlt-1 and/or sEng to induce PreE or HELLP beginning on gestational day 12. After delivery, a battery of validated behavioral assays was used to assess post-partum depression, anxiety and learning. Results: There was no negative effect on maternal pup interaction due to PreE or HELLP; however, hypertensive dams spent more time immobile in the forced swim test (p < 0.0001). Hypertensive dams also spent less time in the open area of the open field (p = 0.001). There were no significant changes in recognition memory (p = 0.08); however, spatial learning was impaired in hypertensive dams (p = 0.003). Immobility time in the forced swim test was positively correlated with increased circulating S100B (p = 0.04), while increased time spent in the outer zones of the open field was negatively correlated with BDNF levels (p < 0.0001). Conclusion: The results from this study suggest that hypertensive pregnancy disorders are associated with depression, anxiety and learning impairments in the post-partum period. MDPI 2022-02-18 /pmc/articles/PMC8869594/ /pubmed/35200304 http://dx.doi.org/10.3390/bs12020053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wallace, Kedra Bowles, Teylor Griffin, Ashley Robinson, Reanna Solis, Lucia Railey, Teryn Shaffery, James P. Araji, Sarah Spencer, Shauna-Kay Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title | Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title_full | Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title_fullStr | Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title_full_unstemmed | Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title_short | Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension |
title_sort | evidence of anxiety, depression and learning impairments following prenatal hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869594/ https://www.ncbi.nlm.nih.gov/pubmed/35200304 http://dx.doi.org/10.3390/bs12020053 |
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