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Ion-Imprinted Polymer-on-a-Sensor for Copper Detection

The accumulation of metal ions in the body is caused by human activities and industrial uses. Among these metal ions, copper is the third most abundant ion found in the human body and is indispensable for health because it works as a catalyst in the iron absorption processes. However, high doses of...

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Autores principales: Gerdan, Zeynep, Saylan, Yeşeren, Uğur, Mukden, Denizli, Adil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869677/
https://www.ncbi.nlm.nih.gov/pubmed/35200351
http://dx.doi.org/10.3390/bios12020091
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author Gerdan, Zeynep
Saylan, Yeşeren
Uğur, Mukden
Denizli, Adil
author_facet Gerdan, Zeynep
Saylan, Yeşeren
Uğur, Mukden
Denizli, Adil
author_sort Gerdan, Zeynep
collection PubMed
description The accumulation of metal ions in the body is caused by human activities and industrial uses. Among these metal ions, copper is the third most abundant ion found in the human body and is indispensable for health because it works as a catalyst in the iron absorption processes. However, high doses of copper ions have been reported to generate various diseases. Different types of sensors are used to detect metal ions for several applications. To design selective and specific recognition sites on the sensor surfaces, molecular imprinting is one of the most used alteration methods to detect targets by mimicking natural recognition molecules. In this study, an ion-imprinted polymer-integrated plasmonic sensor was prepared to selectively detect copper (Cu(II)) ions in real-time. Following different characterization experiments, the Cu(II)-imprinted plasmonic sensor was employed for kinetic, selectivity, and reusability studies. According to the results, it was observed that this sensor can measure with 96% accuracy in the Cu(II) concentration range of 0.04–5 μM in buffer solution. The limit of detection and limit of quantification values were computed as 0.027 µM and 0.089 µM. The results also showed that this plasmonic sensor works successfully not only in a buffer solution but also in complex media such as plasma and urine.
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spelling pubmed-88696772022-02-25 Ion-Imprinted Polymer-on-a-Sensor for Copper Detection Gerdan, Zeynep Saylan, Yeşeren Uğur, Mukden Denizli, Adil Biosensors (Basel) Article The accumulation of metal ions in the body is caused by human activities and industrial uses. Among these metal ions, copper is the third most abundant ion found in the human body and is indispensable for health because it works as a catalyst in the iron absorption processes. However, high doses of copper ions have been reported to generate various diseases. Different types of sensors are used to detect metal ions for several applications. To design selective and specific recognition sites on the sensor surfaces, molecular imprinting is one of the most used alteration methods to detect targets by mimicking natural recognition molecules. In this study, an ion-imprinted polymer-integrated plasmonic sensor was prepared to selectively detect copper (Cu(II)) ions in real-time. Following different characterization experiments, the Cu(II)-imprinted plasmonic sensor was employed for kinetic, selectivity, and reusability studies. According to the results, it was observed that this sensor can measure with 96% accuracy in the Cu(II) concentration range of 0.04–5 μM in buffer solution. The limit of detection and limit of quantification values were computed as 0.027 µM and 0.089 µM. The results also showed that this plasmonic sensor works successfully not only in a buffer solution but also in complex media such as plasma and urine. MDPI 2022-02-02 /pmc/articles/PMC8869677/ /pubmed/35200351 http://dx.doi.org/10.3390/bios12020091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gerdan, Zeynep
Saylan, Yeşeren
Uğur, Mukden
Denizli, Adil
Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title_full Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title_fullStr Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title_full_unstemmed Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title_short Ion-Imprinted Polymer-on-a-Sensor for Copper Detection
title_sort ion-imprinted polymer-on-a-sensor for copper detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869677/
https://www.ncbi.nlm.nih.gov/pubmed/35200351
http://dx.doi.org/10.3390/bios12020091
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