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NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman

Introduction: For more than a decade, NMDAR autoimmune encephalitis has been studied and treated as a neurological condition, and good results have been achieve through immune therapies. Apart from being well represented in the CNS, NMDA receptors are currently known of and being studied in multiple...

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Autores principales: Reisz, Daniela, Gramescu, Iulia-Gabriela, Mihaicuta, Stefan, Popescu, Florina Georgeta, Georgescu, Doina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869825/
https://www.ncbi.nlm.nih.gov/pubmed/35203984
http://dx.doi.org/10.3390/brainsci12020221
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author Reisz, Daniela
Gramescu, Iulia-Gabriela
Mihaicuta, Stefan
Popescu, Florina Georgeta
Georgescu, Doina
author_facet Reisz, Daniela
Gramescu, Iulia-Gabriela
Mihaicuta, Stefan
Popescu, Florina Georgeta
Georgescu, Doina
author_sort Reisz, Daniela
collection PubMed
description Introduction: For more than a decade, NMDAR autoimmune encephalitis has been studied and treated as a neurological condition, and good results have been achieve through immune therapies. Apart from being well represented in the CNS, NMDA receptors are currently known of and being studied in multiple non-neuronal cells with potential clinical significance. The association of NMDAR autoimmune encephalitis with pregnancy is rare, and hypokalemia is not mentioned. Methods: We present the case of a 30-year-old woman with NMDAR autoimmune encephalitis in her 17th week of pregnancy associated with persistent hypokalemia that had no apparent cause and resisted Kalium chloride supplementation. A diagnostic work-up including clinical, laboratory, and imagistic examinations, was performed. The case was monitored between May and September 2016 at Neurology, SCJUT. Results: Severe hypokalemia with normal serum sodium levels persisted throughout the course of clinical manifestation of anti-NMDAR autoimmune encephalitis. Conclusions: NMDAR autoimmune encephalitis is under-diagnosed in its atypical clinical variants, and this disease’s association with hypokalemia is not mentioned in the literature. Still, it is of clinical importance because it attests to the implications of other organs/systems in the general autoimmune process of NMDAR encephalitis, and it might change the way we address certain psychiatric disorders by searching underlying organic conditions.
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spelling pubmed-88698252022-02-25 NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman Reisz, Daniela Gramescu, Iulia-Gabriela Mihaicuta, Stefan Popescu, Florina Georgeta Georgescu, Doina Brain Sci Case Report Introduction: For more than a decade, NMDAR autoimmune encephalitis has been studied and treated as a neurological condition, and good results have been achieve through immune therapies. Apart from being well represented in the CNS, NMDA receptors are currently known of and being studied in multiple non-neuronal cells with potential clinical significance. The association of NMDAR autoimmune encephalitis with pregnancy is rare, and hypokalemia is not mentioned. Methods: We present the case of a 30-year-old woman with NMDAR autoimmune encephalitis in her 17th week of pregnancy associated with persistent hypokalemia that had no apparent cause and resisted Kalium chloride supplementation. A diagnostic work-up including clinical, laboratory, and imagistic examinations, was performed. The case was monitored between May and September 2016 at Neurology, SCJUT. Results: Severe hypokalemia with normal serum sodium levels persisted throughout the course of clinical manifestation of anti-NMDAR autoimmune encephalitis. Conclusions: NMDAR autoimmune encephalitis is under-diagnosed in its atypical clinical variants, and this disease’s association with hypokalemia is not mentioned in the literature. Still, it is of clinical importance because it attests to the implications of other organs/systems in the general autoimmune process of NMDAR encephalitis, and it might change the way we address certain psychiatric disorders by searching underlying organic conditions. MDPI 2022-02-05 /pmc/articles/PMC8869825/ /pubmed/35203984 http://dx.doi.org/10.3390/brainsci12020221 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Reisz, Daniela
Gramescu, Iulia-Gabriela
Mihaicuta, Stefan
Popescu, Florina Georgeta
Georgescu, Doina
NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title_full NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title_fullStr NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title_full_unstemmed NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title_short NMDA Autoimmune Encephalitis and Severe Persistent Hypokalemia in a Pregnant Woman
title_sort nmda autoimmune encephalitis and severe persistent hypokalemia in a pregnant woman
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869825/
https://www.ncbi.nlm.nih.gov/pubmed/35203984
http://dx.doi.org/10.3390/brainsci12020221
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