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Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements

Inclusion body myositis (IBM) is a slowly progressive muscle weakness of distal and proximal muscles, which is diagnosed by clinical and histopathological criteria. Imaging biomarkers are inconsistently used and do not follow international standardized criteria. We conducted a systematic review and...

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Autores principales: Abdelnaby, Ramy, Mohamed, Khaled Ashraf, Elgenidy, Anas, Sonbol, Yousef Tarek, Bedewy, Mahmoud Mostafa, Aboutaleb, Aya Moustafa, Ebrahim, Mohamed Ayman, Maallem, Imene, Dardeer, Khaled Tarek, Heikal, Hamed Amr, Gawish, Hazem Maher, Zschüntzsch, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869828/
https://www.ncbi.nlm.nih.gov/pubmed/35203250
http://dx.doi.org/10.3390/cells11040600
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author Abdelnaby, Ramy
Mohamed, Khaled Ashraf
Elgenidy, Anas
Sonbol, Yousef Tarek
Bedewy, Mahmoud Mostafa
Aboutaleb, Aya Moustafa
Ebrahim, Mohamed Ayman
Maallem, Imene
Dardeer, Khaled Tarek
Heikal, Hamed Amr
Gawish, Hazem Maher
Zschüntzsch, Jana
author_facet Abdelnaby, Ramy
Mohamed, Khaled Ashraf
Elgenidy, Anas
Sonbol, Yousef Tarek
Bedewy, Mahmoud Mostafa
Aboutaleb, Aya Moustafa
Ebrahim, Mohamed Ayman
Maallem, Imene
Dardeer, Khaled Tarek
Heikal, Hamed Amr
Gawish, Hazem Maher
Zschüntzsch, Jana
author_sort Abdelnaby, Ramy
collection PubMed
description Inclusion body myositis (IBM) is a slowly progressive muscle weakness of distal and proximal muscles, which is diagnosed by clinical and histopathological criteria. Imaging biomarkers are inconsistently used and do not follow international standardized criteria. We conducted a systematic review and meta-analysis to investigate the diagnostic value of muscle ultrasound (US) in IBM compared to healthy controls. A systematic search of PubMed/MEDLINE, Scopus and Web of Science was performed. Articles reporting the use of muscle ultrasound in IBM, and published in peer-reviewed journals until 11 September 2021, were included in our study. Seven studies were included, with a total of 108 IBM and 171 healthy controls. Echogenicity between IBM and healthy controls, which was assessed by three studies, demonstrated a significant mean difference in the flexor digitorum profundus (FDP) muscle, which had a grey scale value (GSV) of 36.55 (95% CI, 28.65–44.45, p < 0.001), and in the gastrocnemius (GC), which had a GSV of 27.90 (95% CI 16.32–39.48, p < 0.001). Muscle thickness in the FDP showed no significant difference between the groups. The pooled sensitivity and specificity of US in the differentiation between IBM and the controls were 82% and 98%, respectively, and the area under the curve was 0.612. IBM is a rare disease, which is reflected in the low numbers of patients included in each of the studies and thus there was high heterogeneity in the results. Nevertheless, the selected studies conclusively demonstrated significant differences in echogenicity of the FDP and GC in IBM, compared to controls. Further high-quality studies, using standardized operating procedures, are needed to implement muscle ultrasound in the diagnostic criteria.
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spelling pubmed-88698282022-02-25 Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements Abdelnaby, Ramy Mohamed, Khaled Ashraf Elgenidy, Anas Sonbol, Yousef Tarek Bedewy, Mahmoud Mostafa Aboutaleb, Aya Moustafa Ebrahim, Mohamed Ayman Maallem, Imene Dardeer, Khaled Tarek Heikal, Hamed Amr Gawish, Hazem Maher Zschüntzsch, Jana Cells Systematic Review Inclusion body myositis (IBM) is a slowly progressive muscle weakness of distal and proximal muscles, which is diagnosed by clinical and histopathological criteria. Imaging biomarkers are inconsistently used and do not follow international standardized criteria. We conducted a systematic review and meta-analysis to investigate the diagnostic value of muscle ultrasound (US) in IBM compared to healthy controls. A systematic search of PubMed/MEDLINE, Scopus and Web of Science was performed. Articles reporting the use of muscle ultrasound in IBM, and published in peer-reviewed journals until 11 September 2021, were included in our study. Seven studies were included, with a total of 108 IBM and 171 healthy controls. Echogenicity between IBM and healthy controls, which was assessed by three studies, demonstrated a significant mean difference in the flexor digitorum profundus (FDP) muscle, which had a grey scale value (GSV) of 36.55 (95% CI, 28.65–44.45, p < 0.001), and in the gastrocnemius (GC), which had a GSV of 27.90 (95% CI 16.32–39.48, p < 0.001). Muscle thickness in the FDP showed no significant difference between the groups. The pooled sensitivity and specificity of US in the differentiation between IBM and the controls were 82% and 98%, respectively, and the area under the curve was 0.612. IBM is a rare disease, which is reflected in the low numbers of patients included in each of the studies and thus there was high heterogeneity in the results. Nevertheless, the selected studies conclusively demonstrated significant differences in echogenicity of the FDP and GC in IBM, compared to controls. Further high-quality studies, using standardized operating procedures, are needed to implement muscle ultrasound in the diagnostic criteria. MDPI 2022-02-09 /pmc/articles/PMC8869828/ /pubmed/35203250 http://dx.doi.org/10.3390/cells11040600 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Abdelnaby, Ramy
Mohamed, Khaled Ashraf
Elgenidy, Anas
Sonbol, Yousef Tarek
Bedewy, Mahmoud Mostafa
Aboutaleb, Aya Moustafa
Ebrahim, Mohamed Ayman
Maallem, Imene
Dardeer, Khaled Tarek
Heikal, Hamed Amr
Gawish, Hazem Maher
Zschüntzsch, Jana
Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title_full Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title_fullStr Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title_full_unstemmed Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title_short Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements
title_sort muscle sonography in inclusion body myositis: a systematic review and meta-analysis of 944 measurements
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869828/
https://www.ncbi.nlm.nih.gov/pubmed/35203250
http://dx.doi.org/10.3390/cells11040600
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