Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma

SIMPLE SUMMARY: To decipher the molecular mechanism underlying the resistance of a significant fraction of mantle cell lymphoma (MCL) patients to the first-in-class proteasome inhibitor bortezomib (BTZ), we have characterized the ubiquitin-related proteome (i.e., ubiquitome) of a set of MCL cell lin...

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Detalles Bibliográficos
Autores principales: Quinet, Grégoire, Xolalpa, Wendy, Reyes-Garau, Diana, Profitós-Pelejà, Núria, Azkargorta, Mikel, Ceccato, Laurie, Gonzalez-Santamarta, Maria, Marsal, Maria, Andilla, Jordi, Aillet, Fabienne, Bosch, Francesc, Elortza, Felix, Loza-Alvarez, Pablo, Sola, Brigitte, Coux, Olivier, Matthiesen, Rune, Roué, Gaël, Rodriguez, Manuel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869867/
https://www.ncbi.nlm.nih.gov/pubmed/35205670
http://dx.doi.org/10.3390/cancers14040923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869867/
https://www.ncbi.nlm.nih.gov/pubmed/35205670
http://dx.doi.org/10.3390/cancers14040923

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