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Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration. Analyses of spatially-derived genomic DNA coordinates, such as nuclear speckle-associated domains, lami...

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Detalles Bibliográficos
Autores principales: Singh, Parmit Kumar, Bedwell, Gregory J., Engelman, Alan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869898/
https://www.ncbi.nlm.nih.gov/pubmed/35203306
http://dx.doi.org/10.3390/cells11040655