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Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing

Lanthanide-doped nanoparticles possess numerous advantages including tunable luminescence emission, narrow peak width and excellent optical and thermal stability, especially concerning the long lifetime from microseconds to milliseconds. Differing from other shorter-lifetime fluorescent nanomaterial...

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Detalles Bibliográficos
Autores principales: Wang, Mingkai, Hu, Chuanyu, Su, Qianqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869906/
https://www.ncbi.nlm.nih.gov/pubmed/35200391
http://dx.doi.org/10.3390/bios12020131
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author Wang, Mingkai
Hu, Chuanyu
Su, Qianqian
author_facet Wang, Mingkai
Hu, Chuanyu
Su, Qianqian
author_sort Wang, Mingkai
collection PubMed
description Lanthanide-doped nanoparticles possess numerous advantages including tunable luminescence emission, narrow peak width and excellent optical and thermal stability, especially concerning the long lifetime from microseconds to milliseconds. Differing from other shorter-lifetime fluorescent nanomaterials, the long lifetime of lanthanide-doped nanomaterials is independent with background fluorescence interference and biological tissue depth. This review presents the recent advances in approaches to regulating the lifetime and applications of bioimaging and biodetection. We begin with the introduction of the strategies for regulating the lifetime by modulating the core–shell structure, adjusting the concentration of sensitizer and emitter, changing energy transfer channel, establishing a fluorescence resonance energy transfer pathway and changing temperature. We then summarize the applications of these nanoparticles in biosensing, including ion and molecule detecting, DNA and protease detection, cell labeling, organ imaging and thermal and pH sensing. Finally, the prospects and challenges of the lanthanide lifetime regulation for fundamental research and practical applications are also discussed.
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spelling pubmed-88699062022-02-25 Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing Wang, Mingkai Hu, Chuanyu Su, Qianqian Biosensors (Basel) Review Lanthanide-doped nanoparticles possess numerous advantages including tunable luminescence emission, narrow peak width and excellent optical and thermal stability, especially concerning the long lifetime from microseconds to milliseconds. Differing from other shorter-lifetime fluorescent nanomaterials, the long lifetime of lanthanide-doped nanomaterials is independent with background fluorescence interference and biological tissue depth. This review presents the recent advances in approaches to regulating the lifetime and applications of bioimaging and biodetection. We begin with the introduction of the strategies for regulating the lifetime by modulating the core–shell structure, adjusting the concentration of sensitizer and emitter, changing energy transfer channel, establishing a fluorescence resonance energy transfer pathway and changing temperature. We then summarize the applications of these nanoparticles in biosensing, including ion and molecule detecting, DNA and protease detection, cell labeling, organ imaging and thermal and pH sensing. Finally, the prospects and challenges of the lanthanide lifetime regulation for fundamental research and practical applications are also discussed. MDPI 2022-02-19 /pmc/articles/PMC8869906/ /pubmed/35200391 http://dx.doi.org/10.3390/bios12020131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Mingkai
Hu, Chuanyu
Su, Qianqian
Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title_full Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title_fullStr Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title_full_unstemmed Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title_short Luminescent Lifetime Regulation of Lanthanide-Doped Nanoparticles for Biosensing
title_sort luminescent lifetime regulation of lanthanide-doped nanoparticles for biosensing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869906/
https://www.ncbi.nlm.nih.gov/pubmed/35200391
http://dx.doi.org/10.3390/bios12020131
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