Anti-microRNA-21 Therapy on Top of ACE Inhibition Delays Renal Failure in Alport Syndrome Mouse Models

Col4a3(−/−) Alport mice serve as an animal model for renal fibrosis. MicroRNA-21 (miR-21) expression has been shown to be increased in the kidneys of Alport syndrome patients. Here, we investigated the nephroprotective effects of Lademirsen anti-miR-21 therapy. We used a fast-progressing Col4a3(−/−)...

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Detalles Bibliográficos
Autores principales: Rubel, Diana, Boulanger, Joseph, Craciun, Florin, Xu, Ethan Y., Zhang, Yanqin, Phillips, Lucy, Callahan, Michelle, Weber, William, Song, Wenping, Ngai, Nicholas, Bukanov, Nikolay O., Shi, Xingyi, Hariri, Ali, Husson, Hervé, Ibraghimov-Beskrovnaya, Oxana, Liu, Shiguang, Gross, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869926/
https://www.ncbi.nlm.nih.gov/pubmed/35203245
http://dx.doi.org/10.3390/cells11040594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869926/
https://www.ncbi.nlm.nih.gov/pubmed/35203245
http://dx.doi.org/10.3390/cells11040594

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