Enhanced Autophagic Flux, Suppressed Apoptosis and Reduced Macrophage Infiltration by Dasatinib in Kidneys of Obese Mice

Obesity causes renal changes (ORC), characterized by defective renal autophagy, lipogenesis, enhanced macrophage infiltration and apoptosis. We hypothesize that Dasatinib, a tyrosine kinase inhibitor, may ameliorate changes associated with obesity. We the mice with either Obesogenic diet (OD) or a s...

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Detalles Bibliográficos
Autores principales: Elsayed, Hassan Reda Hassan, El-Gamal, Randa, Rabei, Mohammed R., Elhadidy, Mona G., Hamed, Shereen, Othman, Basma H., Elshaer, Mohamed Mahmoud Abdelraheem, Sedky, Mostafa Khaled, Hassan, Ahmed Tarek Abd Elbaset, El-Nablaway, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869974/
https://www.ncbi.nlm.nih.gov/pubmed/35203394
http://dx.doi.org/10.3390/cells11040746

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