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A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy

Patient: Female, 56-year-old Final Diagnosis: Cerebral venous sinus thrombosis (CVST) Symptoms: Altered mental status • left sided weakness Medication: — Clinical Procedure: Mechanical thrombectomy Specialty: Critical Care Medicine • Neurology OBJECTIVE: Rare disease BACKGROUND: Vaccine-related thro...

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Autores principales: Gurjar, Hitesh, Dhallu, Manjeet, Lvovsky, Dmitry, Sadullah, Samiyah, Chilimuri, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870012/
https://www.ncbi.nlm.nih.gov/pubmed/35181646
http://dx.doi.org/10.12659/AJCR.935355
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author Gurjar, Hitesh
Dhallu, Manjeet
Lvovsky, Dmitry
Sadullah, Samiyah
Chilimuri, Sridhar
author_facet Gurjar, Hitesh
Dhallu, Manjeet
Lvovsky, Dmitry
Sadullah, Samiyah
Chilimuri, Sridhar
author_sort Gurjar, Hitesh
collection PubMed
description Patient: Female, 56-year-old Final Diagnosis: Cerebral venous sinus thrombosis (CVST) Symptoms: Altered mental status • left sided weakness Medication: — Clinical Procedure: Mechanical thrombectomy Specialty: Critical Care Medicine • Neurology OBJECTIVE: Rare disease BACKGROUND: Vaccine-related thrombosis and thrombocytopenia syndrome (TTS) is a rare life-threatening syndrome reported after vaccination against COVID-19. CASE REPORT: We describe a case of 56-year-old postmenopausal, obese woman with hypothyroidism and hyperlipidemia, who presented to the Emergency Department (ED) with fluctuating mental status and left-side weakness for 5 days. She received her first and second dose of mRNA-1273 vaccine (Moderna) at 12 and 8 weeks, respectively, prior to presentation. She was found to have multiple hemorrhages and infarcts on a computed tomography (CT) scan of the head. She was intubated in the ED for airway protection and mechanically ventilated. Magnetic resonance angiogram and venogram showed multiple infarcts in right frontal, parietal, and left parietal lobes, along with occlusion of left-side transverse sinus, sagittal sinuses, and left internal jugular vein, suggesting cerebral venous sinus thrombosis (CVST). Despite anticoagulation, her clinical condition continued to worsen, and she was referred for emergent endovascular thrombectomy. Her clinical condition improved after thrombectomy, and she was discharged on warfarin. At 4-month follow-up, she was able to walk with an assistive device and able to carry out activities of daily living with assistance. She is planned for further work-up for hypercoagulable state at follow-up. CONCLUSIONS: This case highlights the occurrence of vaccine-related thrombosis 3 months after vaccine administration. Only 2 cases of TTS have been reported so far after mRNA-1273 vaccination (Moderna). To the best of our knowledge, this is the first reported case of CVST presenting 3 months after the first dose of COVID-19 mRNA-1273 vaccine (Moderna).
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spelling pubmed-88700122022-03-18 A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy Gurjar, Hitesh Dhallu, Manjeet Lvovsky, Dmitry Sadullah, Samiyah Chilimuri, Sridhar Am J Case Rep Articles Patient: Female, 56-year-old Final Diagnosis: Cerebral venous sinus thrombosis (CVST) Symptoms: Altered mental status • left sided weakness Medication: — Clinical Procedure: Mechanical thrombectomy Specialty: Critical Care Medicine • Neurology OBJECTIVE: Rare disease BACKGROUND: Vaccine-related thrombosis and thrombocytopenia syndrome (TTS) is a rare life-threatening syndrome reported after vaccination against COVID-19. CASE REPORT: We describe a case of 56-year-old postmenopausal, obese woman with hypothyroidism and hyperlipidemia, who presented to the Emergency Department (ED) with fluctuating mental status and left-side weakness for 5 days. She received her first and second dose of mRNA-1273 vaccine (Moderna) at 12 and 8 weeks, respectively, prior to presentation. She was found to have multiple hemorrhages and infarcts on a computed tomography (CT) scan of the head. She was intubated in the ED for airway protection and mechanically ventilated. Magnetic resonance angiogram and venogram showed multiple infarcts in right frontal, parietal, and left parietal lobes, along with occlusion of left-side transverse sinus, sagittal sinuses, and left internal jugular vein, suggesting cerebral venous sinus thrombosis (CVST). Despite anticoagulation, her clinical condition continued to worsen, and she was referred for emergent endovascular thrombectomy. Her clinical condition improved after thrombectomy, and she was discharged on warfarin. At 4-month follow-up, she was able to walk with an assistive device and able to carry out activities of daily living with assistance. She is planned for further work-up for hypercoagulable state at follow-up. CONCLUSIONS: This case highlights the occurrence of vaccine-related thrombosis 3 months after vaccine administration. Only 2 cases of TTS have been reported so far after mRNA-1273 vaccination (Moderna). To the best of our knowledge, this is the first reported case of CVST presenting 3 months after the first dose of COVID-19 mRNA-1273 vaccine (Moderna). International Scientific Literature, Inc. 2022-02-19 /pmc/articles/PMC8870012/ /pubmed/35181646 http://dx.doi.org/10.12659/AJCR.935355 Text en © Am J Case Rep, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Gurjar, Hitesh
Dhallu, Manjeet
Lvovsky, Dmitry
Sadullah, Samiyah
Chilimuri, Sridhar
A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title_full A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title_fullStr A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title_full_unstemmed A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title_short A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Mechanical Thrombectomy
title_sort rare case of coronavirus disease 2019 vaccine-associated cerebral venous sinus thrombosis treated with mechanical thrombectomy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870012/
https://www.ncbi.nlm.nih.gov/pubmed/35181646
http://dx.doi.org/10.12659/AJCR.935355
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