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Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh

Malnourished children are more prone to infectious diseases including severe diarrhea compared to non-malnourished children. However, data are scarce on differences in the presentation in such children. We aimed to identify clinical differentials among children with cholera with or without malnutrit...

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Autores principales: Nuzhat, Sharika, Hossain, Md Iqbal, Shaly, Nusrat Jahan, Islam, Rafiqul, Khan, Soroar Hossain, Faruque, Abu Syed Golam, Bardhan, Pradip Kumar, Khan, Azharul Islam, Chisti, Mohammod Jobayer, Ahmed, Tahmeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870027/
https://www.ncbi.nlm.nih.gov/pubmed/35204858
http://dx.doi.org/10.3390/children9020137
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author Nuzhat, Sharika
Hossain, Md Iqbal
Shaly, Nusrat Jahan
Islam, Rafiqul
Khan, Soroar Hossain
Faruque, Abu Syed Golam
Bardhan, Pradip Kumar
Khan, Azharul Islam
Chisti, Mohammod Jobayer
Ahmed, Tahmeed
author_facet Nuzhat, Sharika
Hossain, Md Iqbal
Shaly, Nusrat Jahan
Islam, Rafiqul
Khan, Soroar Hossain
Faruque, Abu Syed Golam
Bardhan, Pradip Kumar
Khan, Azharul Islam
Chisti, Mohammod Jobayer
Ahmed, Tahmeed
author_sort Nuzhat, Sharika
collection PubMed
description Malnourished children are more prone to infectious diseases including severe diarrhea compared to non-malnourished children. However, data are scarce on differences in the presentation in such children. We aimed to identify clinical differentials among children with cholera with or without malnutrition. Data were extracted from the diarrheal disease surveillance system (DDSS) of Dhaka Hospital of International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) from January 2001 to December 2020. Among children under five in DDSS, cholera positive (culture confirmed) malnourished children (WAZ, WL/HZ or L/HAZ ˂ −2) were considered as cases (n = 920) and children with cholera but non-malnourished (WAZ, WL/HZ or L/HAZ ≥−2.00 to ≤+2.00) were controls (n = 586). After adjusting for potential confounders such as maternal illiteracy, day labor fathers, maternal employment, slum dwelling, non-sanitary latrine use, use of untreated water, and history of cough, it was revealed that malnourished cholera children significantly more often presented in hospital during evening hours (6 p.m. to 12 mid-night) (p < 0.05), had illiterate fathers (p < 0.05), >24 h history of diarrheal duration (p < 0.05), dehydrating diarrhea (p < 0.05), and had longer hospitalization (p < 0.05). The study results underscore the importance of understanding of basic differences in the presentation of severity of cholera in malnourished children for prompt identification and subsequent management of these vulnerable children.
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spelling pubmed-88700272022-02-25 Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh Nuzhat, Sharika Hossain, Md Iqbal Shaly, Nusrat Jahan Islam, Rafiqul Khan, Soroar Hossain Faruque, Abu Syed Golam Bardhan, Pradip Kumar Khan, Azharul Islam Chisti, Mohammod Jobayer Ahmed, Tahmeed Children (Basel) Article Malnourished children are more prone to infectious diseases including severe diarrhea compared to non-malnourished children. However, data are scarce on differences in the presentation in such children. We aimed to identify clinical differentials among children with cholera with or without malnutrition. Data were extracted from the diarrheal disease surveillance system (DDSS) of Dhaka Hospital of International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) from January 2001 to December 2020. Among children under five in DDSS, cholera positive (culture confirmed) malnourished children (WAZ, WL/HZ or L/HAZ ˂ −2) were considered as cases (n = 920) and children with cholera but non-malnourished (WAZ, WL/HZ or L/HAZ ≥−2.00 to ≤+2.00) were controls (n = 586). After adjusting for potential confounders such as maternal illiteracy, day labor fathers, maternal employment, slum dwelling, non-sanitary latrine use, use of untreated water, and history of cough, it was revealed that malnourished cholera children significantly more often presented in hospital during evening hours (6 p.m. to 12 mid-night) (p < 0.05), had illiterate fathers (p < 0.05), >24 h history of diarrheal duration (p < 0.05), dehydrating diarrhea (p < 0.05), and had longer hospitalization (p < 0.05). The study results underscore the importance of understanding of basic differences in the presentation of severity of cholera in malnourished children for prompt identification and subsequent management of these vulnerable children. MDPI 2022-01-20 /pmc/articles/PMC8870027/ /pubmed/35204858 http://dx.doi.org/10.3390/children9020137 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nuzhat, Sharika
Hossain, Md Iqbal
Shaly, Nusrat Jahan
Islam, Rafiqul
Khan, Soroar Hossain
Faruque, Abu Syed Golam
Bardhan, Pradip Kumar
Khan, Azharul Islam
Chisti, Mohammod Jobayer
Ahmed, Tahmeed
Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title_full Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title_fullStr Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title_full_unstemmed Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title_short Different Features of Cholera in Malnourished and Non-Malnourished Children: Analysis of 20 Years of Surveillance Data from a Large Diarrheal Disease Hospital in Urban Bangladesh
title_sort different features of cholera in malnourished and non-malnourished children: analysis of 20 years of surveillance data from a large diarrheal disease hospital in urban bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870027/
https://www.ncbi.nlm.nih.gov/pubmed/35204858
http://dx.doi.org/10.3390/children9020137
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