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Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)

Objective: Recent years saw an increasing interest towards sleep microstructure abnormalities in attention-deficit/hyperactivity disorder (ADHD). However, the existing literature on sleep electroencephalographic (EEG) power in ADHD is still controversial, often based on single electrode recordings,...

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Autores principales: Castelnovo, Anna, Lividini, Althea, Bernardi, Giulio, Pezzoli, Valdo, Foderaro, Giuseppe, Ramelli, Gian Paolo, Manconi, Mauro, Miano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870029/
https://www.ncbi.nlm.nih.gov/pubmed/35204918
http://dx.doi.org/10.3390/children9020197
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author Castelnovo, Anna
Lividini, Althea
Bernardi, Giulio
Pezzoli, Valdo
Foderaro, Giuseppe
Ramelli, Gian Paolo
Manconi, Mauro
Miano, Silvia
author_facet Castelnovo, Anna
Lividini, Althea
Bernardi, Giulio
Pezzoli, Valdo
Foderaro, Giuseppe
Ramelli, Gian Paolo
Manconi, Mauro
Miano, Silvia
author_sort Castelnovo, Anna
collection PubMed
description Objective: Recent years saw an increasing interest towards sleep microstructure abnormalities in attention-deficit/hyperactivity disorder (ADHD). However, the existing literature on sleep electroencephalographic (EEG) power in ADHD is still controversial, often based on single electrode recordings, and mainly focused on slow wave activity (SWA) during NREM sleep. This study aimed to systematically investigate sleep power topography in all traditional frequency bands, in all sleep stages and across sleep cycles using high-density EEG (HD-EEG). Method: Thirty drug-naïve children with ADHD (10.5 ± 2.1 years, 21 male) and 23 typically developing (TD) control participants (mean age: 10.2 ± 1.6 years, 13 male) were included in the current analysis. Signal power topography was computed in classical frequency bands during sleep, contrasted between groups and sleep cycles, and correlated with measures of ADHD severity, cognitive functioning and estimated total sleep time. Results: Compared to TD subjects, patients with ADHD consistently displayed a widespread increase in low-frequency activity (between 3 and 10 Hz) during NREM sleep, but not during REM sleep and wake before sleep onset. Such a difference involved a wide centro-posterior cluster of channels in the upper SWA range, in Theta, and low-Alpha. Between-group difference was maximal in sleep stage N3 in the first sleep cycle, and positively correlated with average total sleep time. Conclusions: These results support the concept that children with ADHD, compared to TD peers, have a higher sleep pressure and altered sleep homeostasis, which possibly interfere with (and delay) cortical maturation.
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spelling pubmed-88700292022-02-25 Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD) Castelnovo, Anna Lividini, Althea Bernardi, Giulio Pezzoli, Valdo Foderaro, Giuseppe Ramelli, Gian Paolo Manconi, Mauro Miano, Silvia Children (Basel) Article Objective: Recent years saw an increasing interest towards sleep microstructure abnormalities in attention-deficit/hyperactivity disorder (ADHD). However, the existing literature on sleep electroencephalographic (EEG) power in ADHD is still controversial, often based on single electrode recordings, and mainly focused on slow wave activity (SWA) during NREM sleep. This study aimed to systematically investigate sleep power topography in all traditional frequency bands, in all sleep stages and across sleep cycles using high-density EEG (HD-EEG). Method: Thirty drug-naïve children with ADHD (10.5 ± 2.1 years, 21 male) and 23 typically developing (TD) control participants (mean age: 10.2 ± 1.6 years, 13 male) were included in the current analysis. Signal power topography was computed in classical frequency bands during sleep, contrasted between groups and sleep cycles, and correlated with measures of ADHD severity, cognitive functioning and estimated total sleep time. Results: Compared to TD subjects, patients with ADHD consistently displayed a widespread increase in low-frequency activity (between 3 and 10 Hz) during NREM sleep, but not during REM sleep and wake before sleep onset. Such a difference involved a wide centro-posterior cluster of channels in the upper SWA range, in Theta, and low-Alpha. Between-group difference was maximal in sleep stage N3 in the first sleep cycle, and positively correlated with average total sleep time. Conclusions: These results support the concept that children with ADHD, compared to TD peers, have a higher sleep pressure and altered sleep homeostasis, which possibly interfere with (and delay) cortical maturation. MDPI 2022-02-03 /pmc/articles/PMC8870029/ /pubmed/35204918 http://dx.doi.org/10.3390/children9020197 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castelnovo, Anna
Lividini, Althea
Bernardi, Giulio
Pezzoli, Valdo
Foderaro, Giuseppe
Ramelli, Gian Paolo
Manconi, Mauro
Miano, Silvia
Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title_full Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title_fullStr Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title_full_unstemmed Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title_short Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD)
title_sort sleep power topography in children with attention deficit hyperactivity disorder (adhd)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870029/
https://www.ncbi.nlm.nih.gov/pubmed/35204918
http://dx.doi.org/10.3390/children9020197
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