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Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings

It is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and cl...

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Autores principales: Omachi, Taichi, Atsumi, Naho, Yamazoe, Takashi, Yamanouchi, Sohsaku, Matsuno, Ryosuke, Kitawaki, Tomoki, Kaneko, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870061/
https://www.ncbi.nlm.nih.gov/pubmed/35205010
http://dx.doi.org/10.3390/children9020290
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author Omachi, Taichi
Atsumi, Naho
Yamazoe, Takashi
Yamanouchi, Sohsaku
Matsuno, Ryosuke
Kitawaki, Tomoki
Kaneko, Kazunari
author_facet Omachi, Taichi
Atsumi, Naho
Yamazoe, Takashi
Yamanouchi, Sohsaku
Matsuno, Ryosuke
Kitawaki, Tomoki
Kaneko, Kazunari
author_sort Omachi, Taichi
collection PubMed
description It is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and clinical findings. We retrospectively analyzed the data from 15 HNL and 13 ML pediatric patients. First, a univariate analysis identified 14 clinical factors with significant differences. Second, a subsequent analysis using receiver operating characteristic (ROC) curve analysis identified three factors among them with area under the ROC curve values of >0.95: body temperature (°C), maximum lymph node size (cm), and serum β(2)-microglobulin level (mg/L). Finally, the cut-off values of each of these three factors were determined and examined for the 28 cases. All 15 HNL cases were within 2–3 of the cut-off values among the three factors, no ML case was within two or more cut-off values. Thus, the diagnostic sensitivity and specificity of this novel scoring system were both 100%, indicating that clinical scoring with body temperature, maximum lymph node size, and β(2)-microglobulin are useful for distinguishing between HNL and ML.
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spelling pubmed-88700612022-02-25 Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings Omachi, Taichi Atsumi, Naho Yamazoe, Takashi Yamanouchi, Sohsaku Matsuno, Ryosuke Kitawaki, Tomoki Kaneko, Kazunari Children (Basel) Article It is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and clinical findings. We retrospectively analyzed the data from 15 HNL and 13 ML pediatric patients. First, a univariate analysis identified 14 clinical factors with significant differences. Second, a subsequent analysis using receiver operating characteristic (ROC) curve analysis identified three factors among them with area under the ROC curve values of >0.95: body temperature (°C), maximum lymph node size (cm), and serum β(2)-microglobulin level (mg/L). Finally, the cut-off values of each of these three factors were determined and examined for the 28 cases. All 15 HNL cases were within 2–3 of the cut-off values among the three factors, no ML case was within two or more cut-off values. Thus, the diagnostic sensitivity and specificity of this novel scoring system were both 100%, indicating that clinical scoring with body temperature, maximum lymph node size, and β(2)-microglobulin are useful for distinguishing between HNL and ML. MDPI 2022-02-20 /pmc/articles/PMC8870061/ /pubmed/35205010 http://dx.doi.org/10.3390/children9020290 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Omachi, Taichi
Atsumi, Naho
Yamazoe, Takashi
Yamanouchi, Sohsaku
Matsuno, Ryosuke
Kitawaki, Tomoki
Kaneko, Kazunari
Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title_full Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title_fullStr Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title_full_unstemmed Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title_short Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
title_sort differential diagnosis of histiocytic necrotizing lymphadenitis and malignant lymphoma with simple clinical findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870061/
https://www.ncbi.nlm.nih.gov/pubmed/35205010
http://dx.doi.org/10.3390/children9020290
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