The Prognostic Role of Intratumoral Stromal Content in Lobular Breast Cancer

SIMPLE SUMMARY: High intratumoral stromal content is related to worse outcomes in several types of cancer. However, its prognostic role in breast cancer seems to differ between different subtypes. High intratumoral stromal content is a negative prognostic marker in triple-negative breast cancer, while the opposite is the case for estrogen-receptor-positive breast cancer, in which higher stromal content is indicative of a better prognosis. Most lobular breast cancers are estrogen-receptor-positive, and the tumor tissue has a clearly defined histological appearance, often with a high intratumoral stromal content. To date, the prognostic role of intratumoral stromal content in lobular breast cancer remains unclear. In this study, we aimed to investigate the prognostic importance of intratumoral stromal content in estrogen-receptor-positive lobular breast cancer. Our results show that high intratumoral stromal content is an easily assessed and clinically useful indicator of a good prognosis in lobular breast cancer. ABSTRACT: Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the importance of intratumoral stromal content for breast cancer-specific mortality (BCM) in a well-defined subgroup (n = 182) of ER+/human-epidermal growth-factor-receptor-2 negative (HER2−) invasive lobular breast cancer (ILC). The intratumoral stromal content was assessed on hematoxylin–eosin-stained whole sections and graded into high stroma (>50%) or low stroma (≤50%). A total of 82 (45%) patients had high-stroma tumors, and 100 (55%) had low-stroma tumors. High-stroma tumors were associated with a lower Nottingham histological grade, low Ki67, and a luminal A-like subtype. After a 10-year follow-up, the patients with high-stroma tumors had a lower BCM (HR: 0.43, 95% CI: 0.21–0.89, p = 0.023) in univariable analysis. Essentially the same effect was found in both the multivariable analysis (10-year follow-up) and univariable analysis (25-year follow-up), but these findings were not strictly significant. In ER+/HER2− ILC, high intratumoral stromal content is an easily assessable histological indicator of a good prognosis.