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Knowns and Unknowns about CAR-T Cell Dysfunction

SIMPLE SUMMARY: The primary issue of adoptive cell therapy is the poor in vivo persistence. In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction. Here we review common dysfunctional states, including exhaustion and senescence, and discuss the challenges associ...

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Detalles Bibliográficos
Autores principales:	Titov, Aleksei, Kaminskiy, Yaroslav, Ganeeva, Irina, Zmievskaya, Ekaterina, Valiullina, Aygul, Rakhmatullina, Aygul, Petukhov, Alexey, Miftakhova, Regina, Rizvanov, Albert, Bulatov, Emil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870103/ https://www.ncbi.nlm.nih.gov/pubmed/35205827 http://dx.doi.org/10.3390/cancers14041078

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