Cargando…

Knowns and Unknowns about CAR-T Cell Dysfunction

SIMPLE SUMMARY: The primary issue of adoptive cell therapy is the poor in vivo persistence. In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction. Here we review common dysfunctional states, including exhaustion and senescence, and discuss the challenges associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Titov, Aleksei, Kaminskiy, Yaroslav, Ganeeva, Irina, Zmievskaya, Ekaterina, Valiullina, Aygul, Rakhmatullina, Aygul, Petukhov, Alexey, Miftakhova, Regina, Rizvanov, Albert, Bulatov, Emil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870103/ https://www.ncbi.nlm.nih.gov/pubmed/35205827 http://dx.doi.org/10.3390/cancers14041078

Ejemplares similares

Adoptive Immunotherapy beyond CAR T-Cells
por: Titov, Aleksei, et al.
Publicado: (2021)

Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections
por: Zmievskaya, Ekaterina, et al.
Publicado: (2021)

Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment
por: Titov, Aleksei, et al.
Publicado: (2020)

Recent Advances in the Development of Bioreactors for Manufacturing of Adoptive Cell Immunotherapies
por: Ganeeva, Irina, et al.
Publicado: (2022)

Evaluation of CAR-T Cells’ Cytotoxicity against Modified Solid Tumor Cell Lines
por: Valiullina, Aigul Kh., et al.
Publicado: (2023)

Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
por: Valiullina, Aigul Kh., et al.
Publicado: (2023)

Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies
por: Chasov, Vitaly, et al.
Publicado: (2021)

Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets
por: Bulatov, Emil, et al.
Publicado: (2018)

Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy
por: Chasov, Vitaly, et al.
Publicado: (2020)

Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion
por: Kaminskiy, Yaroslav, et al.
Publicado: (2022)

Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
por: Bulatov, Emil, et al.
Publicado: (2018)

Adipose-Derived Mesenchymal Stem Cell (MSC) Immortalization by Modulation of hTERT and TP53 Expression Levels
por: Rakhmatullina, Aigul R., et al.
Publicado: (2023)

The biological basis and clinical symptoms of CAR-T therapy-associated toxicites
por: Titov, Aleksei, et al.
Publicado: (2018)

Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?
por: Mirgayazova, Regina, et al.
Publicado: (2020)

The known knowns, known unknowns, and unknown unknowns of surveys and sleep
por: Shaker, Marcus, et al.
Publicado: (2022)

The Ever-Growing Puzzle of Asynchronous Release
por: Rozov, Andrei, et al.
Publicado: (2019)

Sepsis-related stress response: known knowns, known unknowns, and unknown unknowns
por: Peng, Jinmin, et al.
Publicado: (2010)

Known unknowns and unknown unknowns
por: Burki, Talha
Publicado: (2018)

High Triglycerides Are Associated with Low Thrombocyte Counts and High VEGF in Nephropathia Epidemica
por: Martynova, Ekaterina V., et al.
Publicado: (2016)

Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism
por: Hoskisson, Paul A., et al.
Publicado: (2020)

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
por: Watanabe, Keisuke, et al.
Publicado: (2018)

The known and the unknown
Publicado: (2010)

The effect of well-known burn-related features on machine learning algorithms in burn patients’ mortality prediction
por: Yazıcı, Hilmi, et al.
Publicado: (2023)

The Knowns and Unknowns in Protein–Metabolite Interactions
por: Kurbatov, Ilya, et al.
Publicado: (2023)

Mitophagy in yeast: known unknowns and unknown unknowns
por: Abeliovich, Hagai
Publicado: (2023)

Restless Legs Syndrome: Known Knowns and Known Unknowns
por: Antelmi, Elena, et al.
Publicado: (2022)

Known and unknown matter
por: Ellis, Jonathan Richard
Publicado: (1994)

Novel Isatin-based activator of p53 transcriptional functions in tumor cells
por: Mirgayazova, Regina, et al.
Publicado: (2019)

Umbilical Lesions: A Cluster of Known Unknowns and Unknown Unknowns
por: Das, Aditi
Publicado: (2019)

The Role of Polyamine-Dependent Facilitation of Calcium Permeable AMPARs in Short-Term Synaptic Enhancement
por: Rozov, Andrei, et al.
Publicado: (2018)

Knowns and unknowns about congenital hypothyroidism: 2022 update
por: Itonaga, Tomoyo, et al.
Publicado: (2022)

Japanese Encephalitis Virus in Australia: From Known Known to Known Unknown
por: van den Hurk, Andrew F., et al.
Publicado: (2019)

Engineered Accumulation of Bicarbonate in Plant Chloroplasts: Known Knowns and Known Unknowns
por: Rottet, Sarah, et al.
Publicado: (2021)

Renal denervation in the antihypertensive arsenal – knowns and known unknowns
por: Messerli, Franz H., et al.
Publicado: (2023)

Planning for known and unknown risks
por: Brossman, Charles
Publicado: (2016)

Viral Aggregation: The Knowns and Unknowns
por: Pradhan, Swechchha, et al.
Publicado: (2022)

Virophages—Known and Unknown Facts
por: Tokarz-Deptuła, Beata, et al.
Publicado: (2023)

The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration
por: Chen, Jia-Jia, et al.
Publicado: (2023)

Vitamin D deficiency and supplementation in critical illness—the known knowns and known unknowns
por: Nair, Priya, et al.
Publicado: (2018)

Novel approaches for the rational design of PROTAC linkers
por: Zagidullin, Almaz, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q7ldv0vmri48hghljfcueu9hqo