Cargando…

Heterogeneous Heat Absorption Is Complementary to Radiotherapy

SIMPLE SUMMARY: This review shows the advantages of heterogeneous heating of selected malignant cells in harmonic synergy with radiotherapy. The main clinical achievement of this complementary therapy is its extreme safety and minimal adverse effects. Combining the two methods opens a bright perspec...

Descripción completa

Detalles Bibliográficos
Autor principal: Szasz, Andras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870118/
https://www.ncbi.nlm.nih.gov/pubmed/35205649
http://dx.doi.org/10.3390/cancers14040901
_version_ 1784656660926562304
author Szasz, Andras
author_facet Szasz, Andras
author_sort Szasz, Andras
collection PubMed
description SIMPLE SUMMARY: This review shows the advantages of heterogeneous heating of selected malignant cells in harmonic synergy with radiotherapy. The main clinical achievement of this complementary therapy is its extreme safety and minimal adverse effects. Combining the two methods opens a bright perspective, transforming the local radiotherapy to the antitumoral impact on the whole body, destroying the distant metastases by “teaching” the immune system about the overall danger of malignancy. ABSTRACT: (1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue’s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly “nonthermally” excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39–41 °C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J/kg). The two therapies are synergistically combined.
format Online
Article
Text
id pubmed-8870118
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88701182022-02-25 Heterogeneous Heat Absorption Is Complementary to Radiotherapy Szasz, Andras Cancers (Basel) Review SIMPLE SUMMARY: This review shows the advantages of heterogeneous heating of selected malignant cells in harmonic synergy with radiotherapy. The main clinical achievement of this complementary therapy is its extreme safety and minimal adverse effects. Combining the two methods opens a bright perspective, transforming the local radiotherapy to the antitumoral impact on the whole body, destroying the distant metastases by “teaching” the immune system about the overall danger of malignancy. ABSTRACT: (1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue’s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly “nonthermally” excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39–41 °C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J/kg). The two therapies are synergistically combined. MDPI 2022-02-11 /pmc/articles/PMC8870118/ /pubmed/35205649 http://dx.doi.org/10.3390/cancers14040901 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szasz, Andras
Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title_full Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title_fullStr Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title_full_unstemmed Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title_short Heterogeneous Heat Absorption Is Complementary to Radiotherapy
title_sort heterogeneous heat absorption is complementary to radiotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870118/
https://www.ncbi.nlm.nih.gov/pubmed/35205649
http://dx.doi.org/10.3390/cancers14040901
work_keys_str_mv AT szaszandras heterogeneousheatabsorptioniscomplementarytoradiotherapy