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Expression of Autoimmunity-Related Genes in Melanoma

SIMPLE SUMMARY: The present study selected four genes strongly related to autoimmunity. Their expression was found to be significantly altered in melanoma patients according to a multi-validation procedure carried out on 1948 patients. Such genes may represent suitable molecular targets to further i...

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Autores principales: Scatozza, Francesca, Facchiano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870167/
https://www.ncbi.nlm.nih.gov/pubmed/35205739
http://dx.doi.org/10.3390/cancers14040991
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author Scatozza, Francesca
Facchiano, Antonio
author_facet Scatozza, Francesca
Facchiano, Antonio
author_sort Scatozza, Francesca
collection PubMed
description SIMPLE SUMMARY: The present study selected four genes strongly related to autoimmunity. Their expression was found to be significantly altered in melanoma patients according to a multi-validation procedure carried out on 1948 patients. Such genes may represent suitable molecular targets to further investigate the role autoimmunity may play in melanoma setup and development. Our data suggest that autoimmunity may play a beneficial role in melanoma set up, at least to some extent. ABSTRACT: (1) Background. Immune response dysregulation plays a key role in melanoma, as suggested by the substantial prognosis improvement observed under immune-modulation therapy. Similarly, the role of autoimmunity is under large investigation in melanoma and other cancers. (2) Methods. Expression of 98 autoimmunity-related genes was investigated in 1948 individuals (1024 melanoma and 924 healthy controls). Data were derived from four independent databases, namely, GEO in the selection phase, and Ist Online, GEPIA2 and GENT2, in three sequential validation-steps. ROC analyses were performed to measure the ability to discriminate melanoma from controls. Principal Component Analysis (PCA) was used to combine expression data; survival analysis was carried out on the GEPIA2 platform. (3) Results. Expression levels of NOD2, BAX, IL-18 and ADRB2 were found to be significantly different in melanoma vs. controls and discriminate melanoma from controls in an extremely effective way, either as single molecules (AUC > 0.93 in all cases) or as a profile, according to the PCA analysis. Patients showing high-expression of NOD2 and of IL-18 also show a significant survival improvement as compared to low-expression patients. (4) Conclusions. Four genes strongly related to autoimmunity show a significant altered expression in melanoma samples, highlighting the role they may play in melanoma.
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spelling pubmed-88701672022-02-25 Expression of Autoimmunity-Related Genes in Melanoma Scatozza, Francesca Facchiano, Antonio Cancers (Basel) Article SIMPLE SUMMARY: The present study selected four genes strongly related to autoimmunity. Their expression was found to be significantly altered in melanoma patients according to a multi-validation procedure carried out on 1948 patients. Such genes may represent suitable molecular targets to further investigate the role autoimmunity may play in melanoma setup and development. Our data suggest that autoimmunity may play a beneficial role in melanoma set up, at least to some extent. ABSTRACT: (1) Background. Immune response dysregulation plays a key role in melanoma, as suggested by the substantial prognosis improvement observed under immune-modulation therapy. Similarly, the role of autoimmunity is under large investigation in melanoma and other cancers. (2) Methods. Expression of 98 autoimmunity-related genes was investigated in 1948 individuals (1024 melanoma and 924 healthy controls). Data were derived from four independent databases, namely, GEO in the selection phase, and Ist Online, GEPIA2 and GENT2, in three sequential validation-steps. ROC analyses were performed to measure the ability to discriminate melanoma from controls. Principal Component Analysis (PCA) was used to combine expression data; survival analysis was carried out on the GEPIA2 platform. (3) Results. Expression levels of NOD2, BAX, IL-18 and ADRB2 were found to be significantly different in melanoma vs. controls and discriminate melanoma from controls in an extremely effective way, either as single molecules (AUC > 0.93 in all cases) or as a profile, according to the PCA analysis. Patients showing high-expression of NOD2 and of IL-18 also show a significant survival improvement as compared to low-expression patients. (4) Conclusions. Four genes strongly related to autoimmunity show a significant altered expression in melanoma samples, highlighting the role they may play in melanoma. MDPI 2022-02-16 /pmc/articles/PMC8870167/ /pubmed/35205739 http://dx.doi.org/10.3390/cancers14040991 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scatozza, Francesca
Facchiano, Antonio
Expression of Autoimmunity-Related Genes in Melanoma
title Expression of Autoimmunity-Related Genes in Melanoma
title_full Expression of Autoimmunity-Related Genes in Melanoma
title_fullStr Expression of Autoimmunity-Related Genes in Melanoma
title_full_unstemmed Expression of Autoimmunity-Related Genes in Melanoma
title_short Expression of Autoimmunity-Related Genes in Melanoma
title_sort expression of autoimmunity-related genes in melanoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870167/
https://www.ncbi.nlm.nih.gov/pubmed/35205739
http://dx.doi.org/10.3390/cancers14040991
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