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Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia

The superior longitudinal fasciculus (SLF) is a white matter bundle that connects the frontal areas with the parietal areas. As part of the visuospatial attentional network, it may be involved in the development of schizophrenia. Deficit syndrome (DS) is characterized by primary and enduring negativ...

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Autores principales: Podwalski, Piotr, Tyburski, Ernest, Szczygieł, Krzysztof, Rudkowski, Krzysztof, Waszczuk, Katarzyna, Andrusewicz, Wojciech, Kucharska-Mazur, Jolanta, Michalczyk, Anna, Mak, Monika, Cyranka, Katarzyna, Misiak, Błażej, Sagan, Leszek, Samochowiec, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870217/
https://www.ncbi.nlm.nih.gov/pubmed/35204030
http://dx.doi.org/10.3390/brainsci12020267
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author Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Rudkowski, Krzysztof
Waszczuk, Katarzyna
Andrusewicz, Wojciech
Kucharska-Mazur, Jolanta
Michalczyk, Anna
Mak, Monika
Cyranka, Katarzyna
Misiak, Błażej
Sagan, Leszek
Samochowiec, Jerzy
author_facet Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Rudkowski, Krzysztof
Waszczuk, Katarzyna
Andrusewicz, Wojciech
Kucharska-Mazur, Jolanta
Michalczyk, Anna
Mak, Monika
Cyranka, Katarzyna
Misiak, Błażej
Sagan, Leszek
Samochowiec, Jerzy
author_sort Podwalski, Piotr
collection PubMed
description The superior longitudinal fasciculus (SLF) is a white matter bundle that connects the frontal areas with the parietal areas. As part of the visuospatial attentional network, it may be involved in the development of schizophrenia. Deficit syndrome (DS) is characterized by primary and enduring negative symptoms. The present study assessed SLF integrity in DS and nondeficit schizophrenia (NDS) patients and examined possible relationships between it and psychopathology. Twenty-six DS patients, 42 NDS patients, and 36 healthy controls (HC) underwent psychiatric evaluation and diffusion tensor imaging (DTI). After post-processing, fractional anisotropy (FA) values within the SLF were analyzed. Psychopathology was assessed with the Positive and Negative Syndrome Scale, Brief Negative Symptom Scale, and Self-evaluation of Negative Symptoms. The PANSS proxy for the deficit syndrome was used to diagnose DS. NDS patients had lower FA values than HC. DS patients had greater negative symptoms than NDS patients. After differentiating clinical groups and HC, we found no significant correlations between DTI measures and psychopathological dimensions. These results suggest that changes in SLF integrity are related to schizophrenia, and frontoparietal dysconnection plays a role in its etiopathogenesis. We confirmed that DS patients have greater negative psychopathology than NDS patients. These results are preliminary; further studies are needed.
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spelling pubmed-88702172022-02-25 Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Rudkowski, Krzysztof Waszczuk, Katarzyna Andrusewicz, Wojciech Kucharska-Mazur, Jolanta Michalczyk, Anna Mak, Monika Cyranka, Katarzyna Misiak, Błażej Sagan, Leszek Samochowiec, Jerzy Brain Sci Article The superior longitudinal fasciculus (SLF) is a white matter bundle that connects the frontal areas with the parietal areas. As part of the visuospatial attentional network, it may be involved in the development of schizophrenia. Deficit syndrome (DS) is characterized by primary and enduring negative symptoms. The present study assessed SLF integrity in DS and nondeficit schizophrenia (NDS) patients and examined possible relationships between it and psychopathology. Twenty-six DS patients, 42 NDS patients, and 36 healthy controls (HC) underwent psychiatric evaluation and diffusion tensor imaging (DTI). After post-processing, fractional anisotropy (FA) values within the SLF were analyzed. Psychopathology was assessed with the Positive and Negative Syndrome Scale, Brief Negative Symptom Scale, and Self-evaluation of Negative Symptoms. The PANSS proxy for the deficit syndrome was used to diagnose DS. NDS patients had lower FA values than HC. DS patients had greater negative symptoms than NDS patients. After differentiating clinical groups and HC, we found no significant correlations between DTI measures and psychopathological dimensions. These results suggest that changes in SLF integrity are related to schizophrenia, and frontoparietal dysconnection plays a role in its etiopathogenesis. We confirmed that DS patients have greater negative psychopathology than NDS patients. These results are preliminary; further studies are needed. MDPI 2022-02-14 /pmc/articles/PMC8870217/ /pubmed/35204030 http://dx.doi.org/10.3390/brainsci12020267 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Rudkowski, Krzysztof
Waszczuk, Katarzyna
Andrusewicz, Wojciech
Kucharska-Mazur, Jolanta
Michalczyk, Anna
Mak, Monika
Cyranka, Katarzyna
Misiak, Błażej
Sagan, Leszek
Samochowiec, Jerzy
Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title_full Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title_fullStr Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title_full_unstemmed Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title_short Psychopathology and Integrity of the Superior Longitudinal Fasciculus in Deficit and Nondeficit Schizophrenia
title_sort psychopathology and integrity of the superior longitudinal fasciculus in deficit and nondeficit schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870217/
https://www.ncbi.nlm.nih.gov/pubmed/35204030
http://dx.doi.org/10.3390/brainsci12020267
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