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Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review

Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyze...

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Autores principales: Bronz, Gabriel, Consolascio, Danilo, Bianchetti, Mario G., Rinoldi, Pietro O., Betti, Céline, Lava, Sebastiano A. G., Milani, Gregorio P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870368/
https://www.ncbi.nlm.nih.gov/pubmed/35204985
http://dx.doi.org/10.3390/children9020265
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author Bronz, Gabriel
Consolascio, Danilo
Bianchetti, Mario G.
Rinoldi, Pietro O.
Betti, Céline
Lava, Sebastiano A. G.
Milani, Gregorio P.
author_facet Bronz, Gabriel
Consolascio, Danilo
Bianchetti, Mario G.
Rinoldi, Pietro O.
Betti, Céline
Lava, Sebastiano A. G.
Milani, Gregorio P.
author_sort Bronz, Gabriel
collection PubMed
description Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression.
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spelling pubmed-88703682022-02-25 Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review Bronz, Gabriel Consolascio, Danilo Bianchetti, Mario G. Rinoldi, Pietro O. Betti, Céline Lava, Sebastiano A. G. Milani, Gregorio P. Children (Basel) Systematic Review Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression. MDPI 2022-02-15 /pmc/articles/PMC8870368/ /pubmed/35204985 http://dx.doi.org/10.3390/children9020265 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Bronz, Gabriel
Consolascio, Danilo
Bianchetti, Mario G.
Rinoldi, Pietro O.
Betti, Céline
Lava, Sebastiano A. G.
Milani, Gregorio P.
Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title_full Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title_fullStr Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title_full_unstemmed Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title_short Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
title_sort köbner and pastia signs in acute hemorrhagic edema of young children: systematic literature review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870368/
https://www.ncbi.nlm.nih.gov/pubmed/35204985
http://dx.doi.org/10.3390/children9020265
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