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Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review
Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyze...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870368/ https://www.ncbi.nlm.nih.gov/pubmed/35204985 http://dx.doi.org/10.3390/children9020265 |
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author | Bronz, Gabriel Consolascio, Danilo Bianchetti, Mario G. Rinoldi, Pietro O. Betti, Céline Lava, Sebastiano A. G. Milani, Gregorio P. |
author_facet | Bronz, Gabriel Consolascio, Danilo Bianchetti, Mario G. Rinoldi, Pietro O. Betti, Céline Lava, Sebastiano A. G. Milani, Gregorio P. |
author_sort | Bronz, Gabriel |
collection | PubMed |
description | Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression. |
format | Online Article Text |
id | pubmed-8870368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88703682022-02-25 Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review Bronz, Gabriel Consolascio, Danilo Bianchetti, Mario G. Rinoldi, Pietro O. Betti, Céline Lava, Sebastiano A. G. Milani, Gregorio P. Children (Basel) Systematic Review Acute hemorrhagic edema of young children, a benign skin-limited vasculitis, predominantly affects children 2 years of age or younger. The prevalence and clinical features of the Köbner and Pastia signs have never been systematically investigated in this vasculitis. To address this issue, we analyzed the data contained in the Acute Hemorrhagic Edema Bibliographic Database, which incorporates all reports on hemorrhagic edema published after 1969. A total of 339 cases (236 males and 103 females; 11 (8–18) months of age; median and interquartile range) were documented with at least 1 photograph and therefore included in this analysis. The Köbner sign occurred in 24 cases (14 males and 10 females; 11 (7–17) months of age), the Pastia sign in 51 cases (39 males and 12 females; 11 (8–15) months of age), and both Köbner and Pastia signs in 8 cases (7 males and 1 female; 11 (7–17) months of age). The lower legs, thighs, waistline, and groin were the regions that were most commonly affected with the Köbner sign, while the ankle, feet, cubital fossa, and elbow were most affected with the Pastia sign. The Köbner and Pastia signs are clinically relevant; they occur in about every fourth child affected with hemorrhagic edema and do not influence the disease progression. MDPI 2022-02-15 /pmc/articles/PMC8870368/ /pubmed/35204985 http://dx.doi.org/10.3390/children9020265 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Bronz, Gabriel Consolascio, Danilo Bianchetti, Mario G. Rinoldi, Pietro O. Betti, Céline Lava, Sebastiano A. G. Milani, Gregorio P. Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title_full | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title_fullStr | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title_full_unstemmed | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title_short | Köbner and Pastia Signs in Acute Hemorrhagic Edema of Young Children: Systematic Literature Review |
title_sort | köbner and pastia signs in acute hemorrhagic edema of young children: systematic literature review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870368/ https://www.ncbi.nlm.nih.gov/pubmed/35204985 http://dx.doi.org/10.3390/children9020265 |
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