Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signa...

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Detalles Bibliográficos
Autores principales: Sivasudhan, Enakshi, Blake, Neil, Lu, Zhiliang, Meng, Jia, Rong, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870387/
https://www.ncbi.nlm.nih.gov/pubmed/35203390
http://dx.doi.org/10.3390/cells11040741
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author Sivasudhan, Enakshi
Blake, Neil
Lu, Zhiliang
Meng, Jia
Rong, Rong
author_facet Sivasudhan, Enakshi
Blake, Neil
Lu, Zhiliang
Meng, Jia
Rong, Rong
author_sort Sivasudhan, Enakshi
collection PubMed
description With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.
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spelling pubmed-88703872022-02-25 Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review Sivasudhan, Enakshi Blake, Neil Lu, Zhiliang Meng, Jia Rong, Rong Cells Review With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC. MDPI 2022-02-21 /pmc/articles/PMC8870387/ /pubmed/35203390 http://dx.doi.org/10.3390/cells11040741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sivasudhan, Enakshi
Blake, Neil
Lu, Zhiliang
Meng, Jia
Rong, Rong
Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title_full Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title_fullStr Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title_full_unstemmed Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title_short Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
title_sort hepatitis b viral protein hbx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870387/
https://www.ncbi.nlm.nih.gov/pubmed/35203390
http://dx.doi.org/10.3390/cells11040741
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