Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors: Results of Efficacy, Tolerability, and the Translational Study

SIMPLE SUMMARY: Genomic instability (GI) is a transversal phenomenon in oncology, constituting a hallmark of cancer. In gynecological malignancies, the predictive value of GI has been described and is mainly caused by alterations in the homologous recombination repair (HRR) genes, such as BRCA1/2. T...

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Detalles Bibliográficos
Autores principales: Poveda, Andres, Lopez-Reig, Raquel, Oaknin, Ana, Redondo, Andres, Rubio, Maria Jesus, Guerra, Eva, Fariñas-Madrid, Lorena, Gallego, Alejandro, Rodriguez-Freixinos, Victor, Fernandez-Serra, Antonio, Juan, Oscar, Romero, Ignacio, Lopez-Guerrero, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870416/
https://www.ncbi.nlm.nih.gov/pubmed/35205662
http://dx.doi.org/10.3390/cancers14040915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870416/
https://www.ncbi.nlm.nih.gov/pubmed/35205662
http://dx.doi.org/10.3390/cancers14040915

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