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Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression

BACKGROUND: Aberrant DNA methylation acts epigenetically to skew the gene transcription rate up or down, contributing to cancer etiology. A gap in our understanding concerns the epigenomics of stagewise cancer progression. In this study, we have developed a comprehensive computational framework for...

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Detalles Bibliográficos
Autores principales:	Muthamilselvan, Sangeetha, Raghavendran, Abirami, Palaniappan, Ashok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870460/ https://www.ncbi.nlm.nih.gov/pubmed/35202405 http://dx.doi.org/10.1371/journal.pone.0249151

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