The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling

Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by RIG-I/MDA-5. In human and mouse cells lacking Spir-1, IRF3 and NF-κB-de...

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Detalles Bibliográficos
Autores principales: Torres, Alice A., Macilwee, Stephanie L., Rashid, Amir, Cox, Sarah E., Albarnaz, Jonas D., Bonjardim, Claudio A., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870497/
https://www.ncbi.nlm.nih.gov/pubmed/35148361
http://dx.doi.org/10.1371/journal.ppat.1010277

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