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Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome
Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870519/ https://www.ncbi.nlm.nih.gov/pubmed/35203967 http://dx.doi.org/10.3390/brainsci12020204 |
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author | Schuster, Sebastian Beyer, Leonie Palleis, Carla Harris, Stefanie Schmitt, Julia Weidinger, Endy Prix, Catharina Bötzel, Kai Danek, Adrian Rauchmann, Boris-Stephan Stöcklein, Sophia Lindner, Simon Unterrainer, Marcus Albert, Nathalie L. Mittlmeier, Lena M. Wetzel, Christian Rupprecht, Rainer Rominger, Axel Bartenstein, Peter Perneczky, Robert Levin, Johannes Höglinger, Günter U. Brendel, Matthias Dekorsy, Franziska J. |
author_facet | Schuster, Sebastian Beyer, Leonie Palleis, Carla Harris, Stefanie Schmitt, Julia Weidinger, Endy Prix, Catharina Bötzel, Kai Danek, Adrian Rauchmann, Boris-Stephan Stöcklein, Sophia Lindner, Simon Unterrainer, Marcus Albert, Nathalie L. Mittlmeier, Lena M. Wetzel, Christian Rupprecht, Rainer Rominger, Axel Bartenstein, Peter Perneczky, Robert Levin, Johannes Höglinger, Günter U. Brendel, Matthias Dekorsy, Franziska J. |
author_sort | Schuster, Sebastian |
collection | PubMed |
description | Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [(18)F]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [(18)F]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (p = 0.041), the left putamen (p = 0.005), the right putamen (p = 0.038) and the left pallidum (p = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [(18)F]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly. |
format | Online Article Text |
id | pubmed-8870519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88705192022-02-25 Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome Schuster, Sebastian Beyer, Leonie Palleis, Carla Harris, Stefanie Schmitt, Julia Weidinger, Endy Prix, Catharina Bötzel, Kai Danek, Adrian Rauchmann, Boris-Stephan Stöcklein, Sophia Lindner, Simon Unterrainer, Marcus Albert, Nathalie L. Mittlmeier, Lena M. Wetzel, Christian Rupprecht, Rainer Rominger, Axel Bartenstein, Peter Perneczky, Robert Levin, Johannes Höglinger, Günter U. Brendel, Matthias Dekorsy, Franziska J. Brain Sci Article Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [(18)F]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [(18)F]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (p = 0.041), the left putamen (p = 0.005), the right putamen (p = 0.038) and the left pallidum (p = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [(18)F]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly. MDPI 2022-01-31 /pmc/articles/PMC8870519/ /pubmed/35203967 http://dx.doi.org/10.3390/brainsci12020204 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schuster, Sebastian Beyer, Leonie Palleis, Carla Harris, Stefanie Schmitt, Julia Weidinger, Endy Prix, Catharina Bötzel, Kai Danek, Adrian Rauchmann, Boris-Stephan Stöcklein, Sophia Lindner, Simon Unterrainer, Marcus Albert, Nathalie L. Mittlmeier, Lena M. Wetzel, Christian Rupprecht, Rainer Rominger, Axel Bartenstein, Peter Perneczky, Robert Levin, Johannes Höglinger, Günter U. Brendel, Matthias Dekorsy, Franziska J. Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title | Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title_full | Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title_fullStr | Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title_full_unstemmed | Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title_short | Impact of Partial Volume Correction on [(18)F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
title_sort | impact of partial volume correction on [(18)f]ge-180 pet quantification in subcortical brain regions of patients with corticobasal syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870519/ https://www.ncbi.nlm.nih.gov/pubmed/35203967 http://dx.doi.org/10.3390/brainsci12020204 |
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