The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among adults. It is the clonal expansion of B cells expressing CD19 and CD5. Despite significant progress in treatment, CLL is still incurable. γδ T cells comprise an important subset of the cytotoxic T cells. Although γδ T cells in CL...

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Detalles Bibliográficos
Autores principales: Zarobkiewicz, Michał K., Bojarska-Junak, Agnieszka A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870520/
https://www.ncbi.nlm.nih.gov/pubmed/35203309
http://dx.doi.org/10.3390/cells11040661
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author Zarobkiewicz, Michał K.
Bojarska-Junak, Agnieszka A.
author_facet Zarobkiewicz, Michał K.
Bojarska-Junak, Agnieszka A.
author_sort Zarobkiewicz, Michał K.
collection PubMed
description Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among adults. It is the clonal expansion of B cells expressing CD19 and CD5. Despite significant progress in treatment, CLL is still incurable. γδ T cells comprise an important subset of the cytotoxic T cells. Although γδ T cells in CLL are dysfunctional, they still can possibly be used for immunotherapy. The current paper reviews our understanding of γδ T lymphocytes in CLL.
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spelling pubmed-88705202022-02-25 The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL) Zarobkiewicz, Michał K. Bojarska-Junak, Agnieszka A. Cells Review Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among adults. It is the clonal expansion of B cells expressing CD19 and CD5. Despite significant progress in treatment, CLL is still incurable. γδ T cells comprise an important subset of the cytotoxic T cells. Although γδ T cells in CLL are dysfunctional, they still can possibly be used for immunotherapy. The current paper reviews our understanding of γδ T lymphocytes in CLL. MDPI 2022-02-14 /pmc/articles/PMC8870520/ /pubmed/35203309 http://dx.doi.org/10.3390/cells11040661 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zarobkiewicz, Michał K.
Bojarska-Junak, Agnieszka A.
The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title_full The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title_fullStr The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title_full_unstemmed The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title_short The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)
title_sort mysterious actor—γδ t lymphocytes in chronic lymphocytic leukaemia (cll)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870520/
https://www.ncbi.nlm.nih.gov/pubmed/35203309
http://dx.doi.org/10.3390/cells11040661
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