Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease

We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. Furthermore, 3T T1-weighted MR images were used for automated brainstem cal...

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Autores principales: Urso, Daniele, Nigro, Salvatore, Tafuri, Benedetta, Gnoni, Valentina, Filardi, Marco, De Blasi, Roberto, Ray Chaudhuri, K., Logroscino, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870674/
https://www.ncbi.nlm.nih.gov/pubmed/35203966
http://dx.doi.org/10.3390/brainsci12020202
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author Urso, Daniele
Nigro, Salvatore
Tafuri, Benedetta
Gnoni, Valentina
Filardi, Marco
De Blasi, Roberto
Ray Chaudhuri, K.
Logroscino, Giancarlo
author_facet Urso, Daniele
Nigro, Salvatore
Tafuri, Benedetta
Gnoni, Valentina
Filardi, Marco
De Blasi, Roberto
Ray Chaudhuri, K.
Logroscino, Giancarlo
author_sort Urso, Daniele
collection PubMed
description We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. Furthermore, 3T T1-weighted MR images were used for automated brainstem calculations. MRPI values were higher in the PD-RBD (p = 0.004) compared to PD-noRBD patients. Moreover, MRPI proved to be a significant predictor of REM Behavior Disorder Screening Questionnaire scores in PD (β = 0.195, p = 0.007) and iRBD patients (β = 0.582, p = 0.003). MRPI can be used as an imaging marker of RBD in patients with de novo PD and iRBD.
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spelling pubmed-88706742022-02-25 Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease Urso, Daniele Nigro, Salvatore Tafuri, Benedetta Gnoni, Valentina Filardi, Marco De Blasi, Roberto Ray Chaudhuri, K. Logroscino, Giancarlo Brain Sci Communication We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. Furthermore, 3T T1-weighted MR images were used for automated brainstem calculations. MRPI values were higher in the PD-RBD (p = 0.004) compared to PD-noRBD patients. Moreover, MRPI proved to be a significant predictor of REM Behavior Disorder Screening Questionnaire scores in PD (β = 0.195, p = 0.007) and iRBD patients (β = 0.582, p = 0.003). MRPI can be used as an imaging marker of RBD in patients with de novo PD and iRBD. MDPI 2022-01-31 /pmc/articles/PMC8870674/ /pubmed/35203966 http://dx.doi.org/10.3390/brainsci12020202 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Urso, Daniele
Nigro, Salvatore
Tafuri, Benedetta
Gnoni, Valentina
Filardi, Marco
De Blasi, Roberto
Ray Chaudhuri, K.
Logroscino, Giancarlo
Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title_full Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title_fullStr Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title_full_unstemmed Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title_short Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease
title_sort magnetic resonance parkinsonism index is associated with rem sleep behavior disorder in parkinson’s disease
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870674/
https://www.ncbi.nlm.nih.gov/pubmed/35203966
http://dx.doi.org/10.3390/brainsci12020202
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