Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia

Chronic neutrophilic leukemia (CNL) relates to mutational CSF3R activation with membrane proximal CSF3R mutations such as T618I as driver mutations, but the significance of truncating mutations is not clarified. In CNL, concomitant mutations promote disease progression, but insight into longitudinal...

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Detalles Bibliográficos
Autores principales: Adam, Franziska C., Szybinski, Jakub, Halter, Jörg P., Cantoni, Nathan, Wenzel, Friedel, Leonards, Katharina, Brkic, Sime, Passweg, Jakob R., Touw, Ivo, Maxson, Julia E., Meyer, Sara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870680/
https://www.ncbi.nlm.nih.gov/pubmed/35200567
http://dx.doi.org/10.3390/curroncol29020068

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