ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series

ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities. This study aimed to investigate the frequency, association with clinicopathological characteristics, and prognosis of...

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Autores principales: Glückstein, Marie-Isabelle, Dintner, Sebastian, Miller, Silvia, Vlasenko, Dmytro, Schenkirsch, Gerhard, Agaimy, Abbas, Märkl, Bruno, Grosser, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870766/
https://www.ncbi.nlm.nih.gov/pubmed/35204520
http://dx.doi.org/10.3390/diagnostics12020429
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author Glückstein, Marie-Isabelle
Dintner, Sebastian
Miller, Silvia
Vlasenko, Dmytro
Schenkirsch, Gerhard
Agaimy, Abbas
Märkl, Bruno
Grosser, Bianca
author_facet Glückstein, Marie-Isabelle
Dintner, Sebastian
Miller, Silvia
Vlasenko, Dmytro
Schenkirsch, Gerhard
Agaimy, Abbas
Märkl, Bruno
Grosser, Bianca
author_sort Glückstein, Marie-Isabelle
collection PubMed
description ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities. This study aimed to investigate the frequency, association with clinicopathological characteristics, and prognosis of the immunohistochemical expressions of ALK, NUT, and TRK in 477 adenocarcinomas of the stomach and gastroesophageal junction. Seven cases (1.5%) showed an expression of TRK. In NGS, no NTRK fusion was confirmed. No case with ALK or NUT expression was detected. ALK, NUT, and NTRK expression does not seem to play an important role in gastric carcinomas.
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spelling pubmed-88707662022-02-25 ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series Glückstein, Marie-Isabelle Dintner, Sebastian Miller, Silvia Vlasenko, Dmytro Schenkirsch, Gerhard Agaimy, Abbas Märkl, Bruno Grosser, Bianca Diagnostics (Basel) Article ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities. This study aimed to investigate the frequency, association with clinicopathological characteristics, and prognosis of the immunohistochemical expressions of ALK, NUT, and TRK in 477 adenocarcinomas of the stomach and gastroesophageal junction. Seven cases (1.5%) showed an expression of TRK. In NGS, no NTRK fusion was confirmed. No case with ALK or NUT expression was detected. ALK, NUT, and NTRK expression does not seem to play an important role in gastric carcinomas. MDPI 2022-02-07 /pmc/articles/PMC8870766/ /pubmed/35204520 http://dx.doi.org/10.3390/diagnostics12020429 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glückstein, Marie-Isabelle
Dintner, Sebastian
Miller, Silvia
Vlasenko, Dmytro
Schenkirsch, Gerhard
Agaimy, Abbas
Märkl, Bruno
Grosser, Bianca
ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title_full ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title_fullStr ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title_full_unstemmed ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title_short ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
title_sort alk, nut, and trk do not play relevant roles in gastric cancer—results of an immunohistochemical study in a large series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870766/
https://www.ncbi.nlm.nih.gov/pubmed/35204520
http://dx.doi.org/10.3390/diagnostics12020429
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