Cargando…

Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study

Albuminuria is a sensitive marker for renal dysfunction. Urinary dipstick tests are frequently used to screen for urinary abnormalities in the emergency department (ED). The aim of this prospective cohort study is to evaluate the usefulness of urinary dipstick testing as a screening tool for albumin...

Descripción completa

Detalles Bibliográficos
Autores principales: Nielsen, Christian B., Birn, Henrik, Brandt, Frans, Kampmann, Jan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870803/
https://www.ncbi.nlm.nih.gov/pubmed/35204548
http://dx.doi.org/10.3390/diagnostics12020457
_version_ 1784656844372836352
author Nielsen, Christian B.
Birn, Henrik
Brandt, Frans
Kampmann, Jan D.
author_facet Nielsen, Christian B.
Birn, Henrik
Brandt, Frans
Kampmann, Jan D.
author_sort Nielsen, Christian B.
collection PubMed
description Albuminuria is a sensitive marker for renal dysfunction. Urinary dipstick tests are frequently used to screen for urinary abnormalities in the emergency department (ED). The aim of this prospective cohort study is to evaluate the usefulness of urinary dipstick testing as a screening tool for albuminuria in the ED setting and to determine the persistency of albuminuria identified in the acute setting. Urinary dipstick tests and spot urine samples were obtained simultaneously for analysis of the urinary albumin-creatinine ratio (ACR). Participants with positive dipsticks for protein were invited for a second urinalysis four to six weeks after admission. The study included 234 patients admitted to the ED. Urinalysis was performed on 178 patients of which 46% (n = 82) had positive urinary dipstick tests for proteinuria. The sensitivity and specificity of the dipstick test were low (72.7% and 55.7% respectively) when compared to the ACR. Of the 82 patients with positive dipsticks at admission, 35 were available for follow-up. We observed a significant reduction in ACR at follow-up when compared to ACR at admission (p = 0.004). This paper concludes that urinary dipstick tests are not a reliable means to screen for albuminuria in the ED setting.
format Online
Article
Text
id pubmed-8870803
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88708032022-02-25 Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study Nielsen, Christian B. Birn, Henrik Brandt, Frans Kampmann, Jan D. Diagnostics (Basel) Article Albuminuria is a sensitive marker for renal dysfunction. Urinary dipstick tests are frequently used to screen for urinary abnormalities in the emergency department (ED). The aim of this prospective cohort study is to evaluate the usefulness of urinary dipstick testing as a screening tool for albuminuria in the ED setting and to determine the persistency of albuminuria identified in the acute setting. Urinary dipstick tests and spot urine samples were obtained simultaneously for analysis of the urinary albumin-creatinine ratio (ACR). Participants with positive dipsticks for protein were invited for a second urinalysis four to six weeks after admission. The study included 234 patients admitted to the ED. Urinalysis was performed on 178 patients of which 46% (n = 82) had positive urinary dipstick tests for proteinuria. The sensitivity and specificity of the dipstick test were low (72.7% and 55.7% respectively) when compared to the ACR. Of the 82 patients with positive dipsticks at admission, 35 were available for follow-up. We observed a significant reduction in ACR at follow-up when compared to ACR at admission (p = 0.004). This paper concludes that urinary dipstick tests are not a reliable means to screen for albuminuria in the ED setting. MDPI 2022-02-10 /pmc/articles/PMC8870803/ /pubmed/35204548 http://dx.doi.org/10.3390/diagnostics12020457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nielsen, Christian B.
Birn, Henrik
Brandt, Frans
Kampmann, Jan D.
Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title_full Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title_fullStr Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title_full_unstemmed Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title_short Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
title_sort urinary dipstick is not reliable as a screening tool for albuminuria in the emergency department—a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870803/
https://www.ncbi.nlm.nih.gov/pubmed/35204548
http://dx.doi.org/10.3390/diagnostics12020457
work_keys_str_mv AT nielsenchristianb urinarydipstickisnotreliableasascreeningtoolforalbuminuriaintheemergencydepartmentaprospectivecohortstudy
AT birnhenrik urinarydipstickisnotreliableasascreeningtoolforalbuminuriaintheemergencydepartmentaprospectivecohortstudy
AT brandtfrans urinarydipstickisnotreliableasascreeningtoolforalbuminuriaintheemergencydepartmentaprospectivecohortstudy
AT kampmannjand urinarydipstickisnotreliableasascreeningtoolforalbuminuriaintheemergencydepartmentaprospectivecohortstudy