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Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells

The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed–Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplasti...

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Autores principales: Di Napoli, Arianna, Rogges, Evelina, Noccioli, Niccolò, Gazzola, Anna, Lopez, Gianluca, Persechino, Severino, Mancini, Rita, Sabattini, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870847/
https://www.ncbi.nlm.nih.gov/pubmed/35204381
http://dx.doi.org/10.3390/diagnostics12020290
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author Di Napoli, Arianna
Rogges, Evelina
Noccioli, Niccolò
Gazzola, Anna
Lopez, Gianluca
Persechino, Severino
Mancini, Rita
Sabattini, Elena
author_facet Di Napoli, Arianna
Rogges, Evelina
Noccioli, Niccolò
Gazzola, Anna
Lopez, Gianluca
Persechino, Severino
Mancini, Rita
Sabattini, Elena
author_sort Di Napoli, Arianna
collection PubMed
description The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed–Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations.
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spelling pubmed-88708472022-02-25 Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells Di Napoli, Arianna Rogges, Evelina Noccioli, Niccolò Gazzola, Anna Lopez, Gianluca Persechino, Severino Mancini, Rita Sabattini, Elena Diagnostics (Basel) Communication The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed–Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations. MDPI 2022-01-24 /pmc/articles/PMC8870847/ /pubmed/35204381 http://dx.doi.org/10.3390/diagnostics12020290 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Di Napoli, Arianna
Rogges, Evelina
Noccioli, Niccolò
Gazzola, Anna
Lopez, Gianluca
Persechino, Severino
Mancini, Rita
Sabattini, Elena
Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title_full Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title_fullStr Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title_full_unstemmed Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title_short Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
title_sort deep sequencing of immunoglobulin genes identifies a very low percentage of monoclonal b cells in primary cutaneous marginal zone lymphomas with cd30-positive hodgkin/reed–sternberg-like cells
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870847/
https://www.ncbi.nlm.nih.gov/pubmed/35204381
http://dx.doi.org/10.3390/diagnostics12020290
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