Cargando…
Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients
Background: Generally, little is known about prognostic factors in bladder cancer patients under 40 years of age. We therefore performed a retrospective study to identify prognostic factors in these younger bladder cancer patients. Methods: We collected clinicopathological data on bladder cancer pat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870851/ https://www.ncbi.nlm.nih.gov/pubmed/35200552 http://dx.doi.org/10.3390/curroncol29020052 |
_version_ | 1784656856082284544 |
---|---|
author | Abudurexiti, Mierxiati Ma, Jie Li, Yao Hu, Chuanyi Cai, Zhikang Wang, Zhong Jiang, Ning |
author_facet | Abudurexiti, Mierxiati Ma, Jie Li, Yao Hu, Chuanyi Cai, Zhikang Wang, Zhong Jiang, Ning |
author_sort | Abudurexiti, Mierxiati |
collection | PubMed |
description | Background: Generally, little is known about prognostic factors in bladder cancer patients under 40 years of age. We therefore performed a retrospective study to identify prognostic factors in these younger bladder cancer patients. Methods: We collected clinicopathological data on bladder cancer patients ≤40 years old diagnosed between 1975 and 2018 from the Surveillance, Epidemiology, and End Results (SEER) database. Survival curves were generated using the Kaplan–Meier method, and the differences between groups were analyzed using the log-rank test. Univariate and multivariate Cox hazards regression analyses were performed to define hazard ratios (HRs) for cancer-specific survival (CSS). Results: There were statistical differences in race, histological type, cancer stage, tumor size, and surgery treatment groups between overall survival and CSS. Only tumor size and cancer stage were significant independent prognostic risk factors in younger bladder cancer patients for the prediction of CSS. Conclusion: Tumors greater than 30 mm in size and a more advanced stage of bladder cancer were indicative of a poor prognosis in bladder cancer patients ≤40 years old, and long-term follow-up is suggested. |
format | Online Article Text |
id | pubmed-8870851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88708512022-02-25 Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients Abudurexiti, Mierxiati Ma, Jie Li, Yao Hu, Chuanyi Cai, Zhikang Wang, Zhong Jiang, Ning Curr Oncol Article Background: Generally, little is known about prognostic factors in bladder cancer patients under 40 years of age. We therefore performed a retrospective study to identify prognostic factors in these younger bladder cancer patients. Methods: We collected clinicopathological data on bladder cancer patients ≤40 years old diagnosed between 1975 and 2018 from the Surveillance, Epidemiology, and End Results (SEER) database. Survival curves were generated using the Kaplan–Meier method, and the differences between groups were analyzed using the log-rank test. Univariate and multivariate Cox hazards regression analyses were performed to define hazard ratios (HRs) for cancer-specific survival (CSS). Results: There were statistical differences in race, histological type, cancer stage, tumor size, and surgery treatment groups between overall survival and CSS. Only tumor size and cancer stage were significant independent prognostic risk factors in younger bladder cancer patients for the prediction of CSS. Conclusion: Tumors greater than 30 mm in size and a more advanced stage of bladder cancer were indicative of a poor prognosis in bladder cancer patients ≤40 years old, and long-term follow-up is suggested. MDPI 2022-01-28 /pmc/articles/PMC8870851/ /pubmed/35200552 http://dx.doi.org/10.3390/curroncol29020052 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abudurexiti, Mierxiati Ma, Jie Li, Yao Hu, Chuanyi Cai, Zhikang Wang, Zhong Jiang, Ning Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title | Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title_full | Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title_fullStr | Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title_full_unstemmed | Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title_short | Clinical Outcomes and Prognosis Analysis of Younger Bladder Cancer Patients |
title_sort | clinical outcomes and prognosis analysis of younger bladder cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870851/ https://www.ncbi.nlm.nih.gov/pubmed/35200552 http://dx.doi.org/10.3390/curroncol29020052 |
work_keys_str_mv | AT abudurexitimierxiati clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT majie clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT liyao clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT huchuanyi clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT caizhikang clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT wangzhong clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients AT jiangning clinicaloutcomesandprognosisanalysisofyoungerbladdercancerpatients |