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Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach

There are still many questions remaining about the etiopathogenesis of thyroid cancer, the most common type of endocrine neoplasia. Numerous occupational and environmental exposures have been shown to represent important risk factors that increase its incidence. Updated information about thyroid can...

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Autores principales: Berinde, Gabriela Maria, Socaciu, Andreea Iulia, Socaciu, Mihai Adrian, Cozma, Andreea, Rajnoveanu, Armand Gabriel, Petre, Gabriel Emil, Piciu, Doina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870864/
https://www.ncbi.nlm.nih.gov/pubmed/35204408
http://dx.doi.org/10.3390/diagnostics12020318
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author Berinde, Gabriela Maria
Socaciu, Andreea Iulia
Socaciu, Mihai Adrian
Cozma, Andreea
Rajnoveanu, Armand Gabriel
Petre, Gabriel Emil
Piciu, Doina
author_facet Berinde, Gabriela Maria
Socaciu, Andreea Iulia
Socaciu, Mihai Adrian
Cozma, Andreea
Rajnoveanu, Armand Gabriel
Petre, Gabriel Emil
Piciu, Doina
author_sort Berinde, Gabriela Maria
collection PubMed
description There are still many questions remaining about the etiopathogenesis of thyroid cancer, the most common type of endocrine neoplasia. Numerous occupational and environmental exposures have been shown to represent important risk factors that increase its incidence. Updated information about thyroid cancer diagnostics related to occupational and environmental risk factors is reviewed here, considering an integrated risk assessment approach; new data concerning thyroid cancer etiology and pathogenesis mechanisms, diagnostic biomarkers and methodologies, and risk factors involved in its pathogenesis are presented. A special emphasis is dedicated to specific occupational risk factors and to the association between environmental risk agents and thyroid cancer development. The occupational environment is taken into consideration, i.e., the current workplace and previous jobs, as well as data regarding risk factors, e.g., age, gender, family history, lifestyle, use of chemicals, or radiation exposure outside the workplace. Finally, an integrative approach is presented, underlying the need for an accurate Risk Assessment Matrix based on a systematic questionnaire. We propose a complex experimental design that contains different inclusion and exclusion criteria for patient groups, detailed working protocols for achieving coherent and sustainable, well-defined research stages from sample collection to the identification of biomarkers, with correlations between specific oncometabolites integrated into the Risk Assessment Matrix.
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spelling pubmed-88708642022-02-25 Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach Berinde, Gabriela Maria Socaciu, Andreea Iulia Socaciu, Mihai Adrian Cozma, Andreea Rajnoveanu, Armand Gabriel Petre, Gabriel Emil Piciu, Doina Diagnostics (Basel) Review There are still many questions remaining about the etiopathogenesis of thyroid cancer, the most common type of endocrine neoplasia. Numerous occupational and environmental exposures have been shown to represent important risk factors that increase its incidence. Updated information about thyroid cancer diagnostics related to occupational and environmental risk factors is reviewed here, considering an integrated risk assessment approach; new data concerning thyroid cancer etiology and pathogenesis mechanisms, diagnostic biomarkers and methodologies, and risk factors involved in its pathogenesis are presented. A special emphasis is dedicated to specific occupational risk factors and to the association between environmental risk agents and thyroid cancer development. The occupational environment is taken into consideration, i.e., the current workplace and previous jobs, as well as data regarding risk factors, e.g., age, gender, family history, lifestyle, use of chemicals, or radiation exposure outside the workplace. Finally, an integrative approach is presented, underlying the need for an accurate Risk Assessment Matrix based on a systematic questionnaire. We propose a complex experimental design that contains different inclusion and exclusion criteria for patient groups, detailed working protocols for achieving coherent and sustainable, well-defined research stages from sample collection to the identification of biomarkers, with correlations between specific oncometabolites integrated into the Risk Assessment Matrix. MDPI 2022-01-27 /pmc/articles/PMC8870864/ /pubmed/35204408 http://dx.doi.org/10.3390/diagnostics12020318 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Berinde, Gabriela Maria
Socaciu, Andreea Iulia
Socaciu, Mihai Adrian
Cozma, Andreea
Rajnoveanu, Armand Gabriel
Petre, Gabriel Emil
Piciu, Doina
Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title_full Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title_fullStr Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title_full_unstemmed Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title_short Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
title_sort thyroid cancer diagnostics related to occupational and environmental risk factors: an integrated risk assessment approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870864/
https://www.ncbi.nlm.nih.gov/pubmed/35204408
http://dx.doi.org/10.3390/diagnostics12020318
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