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Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity

The function of natural killer (NK) cells in inflammation has not been explored enough in large-scale population studies. The cross-sectional and time-dependent relationship between NK cell activity (NKA) and inflammatory markers was examined. Methods: A total of 7031 subjects were involved in the c...

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Autores principales: Lee, Yun-Kyong, Haam, Ji-Hee, Cho, Sung-Hoon, Kim, Young-Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870889/
https://www.ncbi.nlm.nih.gov/pubmed/35204539
http://dx.doi.org/10.3390/diagnostics12020448
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author Lee, Yun-Kyong
Haam, Ji-Hee
Cho, Sung-Hoon
Kim, Young-Sang
author_facet Lee, Yun-Kyong
Haam, Ji-Hee
Cho, Sung-Hoon
Kim, Young-Sang
author_sort Lee, Yun-Kyong
collection PubMed
description The function of natural killer (NK) cells in inflammation has not been explored enough in large-scale population studies. The cross-sectional and time-dependent relationship between NK cell activity (NKA) and inflammatory markers was examined. Methods: A total of 7031 subjects were involved in the cross-sectional analyses. Non-linear relationship between NKA and inflammatory indices was analyzed using generalized additive models. The time-dependent changes were analyzed in 1005 subjects with repeated measurement in 3–6 months. The changes in inflammatory markers were analyzed based on the changes in NKA. Results: As NKA reduces to a very low level, the white blood cell (WBC) and neutrophil counts increase sharply, and the lymphocyte count exhibits a slow decline. With increasing NKA larger than about 500 pg/mL, WBC and neutrophil-lymphocyte ratio (NLR) reduces in a mild slope. Among the subjects with repeated measurements, the follow-up NKA was increased with advancing baseline NKA levels. The subjects with a reduction in NKA indicated increment in WBC count, neutrophil count, and NLR, and decrease in lymphocyte count. Conclusions: Very low levels of NKA suggest a high inflammatory immune response. The changes in NKA may interact with the balance between neutrophils and lymphocytes.
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spelling pubmed-88708892022-02-25 Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity Lee, Yun-Kyong Haam, Ji-Hee Cho, Sung-Hoon Kim, Young-Sang Diagnostics (Basel) Article The function of natural killer (NK) cells in inflammation has not been explored enough in large-scale population studies. The cross-sectional and time-dependent relationship between NK cell activity (NKA) and inflammatory markers was examined. Methods: A total of 7031 subjects were involved in the cross-sectional analyses. Non-linear relationship between NKA and inflammatory indices was analyzed using generalized additive models. The time-dependent changes were analyzed in 1005 subjects with repeated measurement in 3–6 months. The changes in inflammatory markers were analyzed based on the changes in NKA. Results: As NKA reduces to a very low level, the white blood cell (WBC) and neutrophil counts increase sharply, and the lymphocyte count exhibits a slow decline. With increasing NKA larger than about 500 pg/mL, WBC and neutrophil-lymphocyte ratio (NLR) reduces in a mild slope. Among the subjects with repeated measurements, the follow-up NKA was increased with advancing baseline NKA levels. The subjects with a reduction in NKA indicated increment in WBC count, neutrophil count, and NLR, and decrease in lymphocyte count. Conclusions: Very low levels of NKA suggest a high inflammatory immune response. The changes in NKA may interact with the balance between neutrophils and lymphocytes. MDPI 2022-02-09 /pmc/articles/PMC8870889/ /pubmed/35204539 http://dx.doi.org/10.3390/diagnostics12020448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yun-Kyong
Haam, Ji-Hee
Cho, Sung-Hoon
Kim, Young-Sang
Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title_full Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title_fullStr Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title_full_unstemmed Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title_short Cross-Sectional and Time-Dependent Analyses on Inflammatory Markers following Natural Killer Cell Activity
title_sort cross-sectional and time-dependent analyses on inflammatory markers following natural killer cell activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870889/
https://www.ncbi.nlm.nih.gov/pubmed/35204539
http://dx.doi.org/10.3390/diagnostics12020448
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