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Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State

Soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) are reported to protect against excessive TNF-α, a primary mediator of systemic responses to infection. This study aimed to investigate the levels of TNF-α, sTNF-R1, and sTNF-R2 in saliva and to verify whether their dynamics are a...

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Autores principales: Kibune, Ryota, Muraoka, Kosuke, Morishita, Masaki, Ariyoshi, Wataru, Awano, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870908/
https://www.ncbi.nlm.nih.gov/pubmed/35200250
http://dx.doi.org/10.3390/dj10020025
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author Kibune, Ryota
Muraoka, Kosuke
Morishita, Masaki
Ariyoshi, Wataru
Awano, Shuji
author_facet Kibune, Ryota
Muraoka, Kosuke
Morishita, Masaki
Ariyoshi, Wataru
Awano, Shuji
author_sort Kibune, Ryota
collection PubMed
description Soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) are reported to protect against excessive TNF-α, a primary mediator of systemic responses to infection. This study aimed to investigate the levels of TNF-α, sTNF-R1, and sTNF-R2 in saliva and to verify whether their dynamics are associated with periodontal health. The study population comprised 28 adult patients. Probing pocket depth, clinical attachment level, and bleeding on probing were assessed, and periodontal inflamed surface area (PISA) was calculated. Stimulated saliva was collected before the oral examinations. The levels of TNF-α, sTNF-R1, sTNF-R2, and total protein (TP) in saliva samples were determined. There were significant positive correlations between TNF-α, sTNF-R1, and sTNF-R2 to TP (/TP) in stimulated saliva. Moreover, there were significant positive correlations between PISA and sTNF-R2/TP. Stepwise multiple regression analysis revealed that PISA was significantly associated with sTNF-R2/TP in saliva; however, TNF-α/TP was not significantly associated with PISA. In conclusion, this study demonstrates that significant relationships exist between the salivary levels of TNF-α and sTNF-R1, and that salivary sTNF-R2 is associated with the expansion of inflamed periodontal tissue.
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spelling pubmed-88709082022-02-25 Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State Kibune, Ryota Muraoka, Kosuke Morishita, Masaki Ariyoshi, Wataru Awano, Shuji Dent J (Basel) Article Soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) are reported to protect against excessive TNF-α, a primary mediator of systemic responses to infection. This study aimed to investigate the levels of TNF-α, sTNF-R1, and sTNF-R2 in saliva and to verify whether their dynamics are associated with periodontal health. The study population comprised 28 adult patients. Probing pocket depth, clinical attachment level, and bleeding on probing were assessed, and periodontal inflamed surface area (PISA) was calculated. Stimulated saliva was collected before the oral examinations. The levels of TNF-α, sTNF-R1, sTNF-R2, and total protein (TP) in saliva samples were determined. There were significant positive correlations between TNF-α, sTNF-R1, and sTNF-R2 to TP (/TP) in stimulated saliva. Moreover, there were significant positive correlations between PISA and sTNF-R2/TP. Stepwise multiple regression analysis revealed that PISA was significantly associated with sTNF-R2/TP in saliva; however, TNF-α/TP was not significantly associated with PISA. In conclusion, this study demonstrates that significant relationships exist between the salivary levels of TNF-α and sTNF-R1, and that salivary sTNF-R2 is associated with the expansion of inflamed periodontal tissue. MDPI 2022-02-08 /pmc/articles/PMC8870908/ /pubmed/35200250 http://dx.doi.org/10.3390/dj10020025 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kibune, Ryota
Muraoka, Kosuke
Morishita, Masaki
Ariyoshi, Wataru
Awano, Shuji
Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title_full Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title_fullStr Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title_full_unstemmed Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title_short Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State
title_sort relationship between dynamics of tnf-α and its soluble receptors in saliva and periodontal health state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870908/
https://www.ncbi.nlm.nih.gov/pubmed/35200250
http://dx.doi.org/10.3390/dj10020025
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