Cargando…
Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) c...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870939/ https://www.ncbi.nlm.nih.gov/pubmed/35204590 http://dx.doi.org/10.3390/diagnostics12020500 |
_version_ | 1784656876994035712 |
---|---|
author | Zhang, Xiu-Juan Lau, Yi-Han Wang, Yu-Meng Chan, Hei-Nga Chan, Poemen P. Kam, Ka-Wai Ip, Patrick Zhang, Wei Young, Alvin L. Tham, Clement C. Pang, Chi-Pui Chen, Li-Jia Yam, Jason C. |
author_facet | Zhang, Xiu-Juan Lau, Yi-Han Wang, Yu-Meng Chan, Hei-Nga Chan, Poemen P. Kam, Ka-Wai Ip, Patrick Zhang, Wei Young, Alvin L. Tham, Clement C. Pang, Chi-Pui Chen, Li-Jia Yam, Jason C. |
author_sort | Zhang, Xiu-Juan |
collection | PubMed |
description | This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, −2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects. |
format | Online Article Text |
id | pubmed-8870939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88709392022-02-25 Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study Zhang, Xiu-Juan Lau, Yi-Han Wang, Yu-Meng Chan, Hei-Nga Chan, Poemen P. Kam, Ka-Wai Ip, Patrick Zhang, Wei Young, Alvin L. Tham, Clement C. Pang, Chi-Pui Chen, Li-Jia Yam, Jason C. Diagnostics (Basel) Article This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, −2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects. MDPI 2022-02-15 /pmc/articles/PMC8870939/ /pubmed/35204590 http://dx.doi.org/10.3390/diagnostics12020500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Xiu-Juan Lau, Yi-Han Wang, Yu-Meng Chan, Hei-Nga Chan, Poemen P. Kam, Ka-Wai Ip, Patrick Zhang, Wei Young, Alvin L. Tham, Clement C. Pang, Chi-Pui Chen, Li-Jia Yam, Jason C. Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title_full | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title_fullStr | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title_full_unstemmed | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title_short | Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study |
title_sort | thicker retinal nerve fiber layer with age among schoolchildren: the hong kong children eye study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870939/ https://www.ncbi.nlm.nih.gov/pubmed/35204590 http://dx.doi.org/10.3390/diagnostics12020500 |
work_keys_str_mv | AT zhangxiujuan thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT lauyihan thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT wangyumeng thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT chanheinga thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT chanpoemenp thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT kamkawai thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT ippatrick thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT zhangwei thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT youngalvinl thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT thamclementc thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT pangchipui thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT chenlijia thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy AT yamjasonc thickerretinalnervefiberlayerwithageamongschoolchildrenthehongkongchildreneyestudy |