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Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study

This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) c...

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Autores principales: Zhang, Xiu-Juan, Lau, Yi-Han, Wang, Yu-Meng, Chan, Hei-Nga, Chan, Poemen P., Kam, Ka-Wai, Ip, Patrick, Zhang, Wei, Young, Alvin L., Tham, Clement C., Pang, Chi-Pui, Chen, Li-Jia, Yam, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870939/
https://www.ncbi.nlm.nih.gov/pubmed/35204590
http://dx.doi.org/10.3390/diagnostics12020500
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author Zhang, Xiu-Juan
Lau, Yi-Han
Wang, Yu-Meng
Chan, Hei-Nga
Chan, Poemen P.
Kam, Ka-Wai
Ip, Patrick
Zhang, Wei
Young, Alvin L.
Tham, Clement C.
Pang, Chi-Pui
Chen, Li-Jia
Yam, Jason C.
author_facet Zhang, Xiu-Juan
Lau, Yi-Han
Wang, Yu-Meng
Chan, Hei-Nga
Chan, Poemen P.
Kam, Ka-Wai
Ip, Patrick
Zhang, Wei
Young, Alvin L.
Tham, Clement C.
Pang, Chi-Pui
Chen, Li-Jia
Yam, Jason C.
author_sort Zhang, Xiu-Juan
collection PubMed
description This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, −2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects.
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spelling pubmed-88709392022-02-25 Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study Zhang, Xiu-Juan Lau, Yi-Han Wang, Yu-Meng Chan, Hei-Nga Chan, Poemen P. Kam, Ka-Wai Ip, Patrick Zhang, Wei Young, Alvin L. Tham, Clement C. Pang, Chi-Pui Chen, Li-Jia Yam, Jason C. Diagnostics (Basel) Article This study aims to investigate the effect of age on the peripapillary retinal nerve fiber layer (p-RNFL) thickness among schoolchildren. A total of 4034 children aged 6–8 years old received comprehensive ophthalmological examinations. p-RNFL thickness was measured from a circular scan (⌀ = 3.4 mm) captured using spectral-domain optical coherence tomography (SD-OCT). Associations between p-RNFL thickness with ocular and systemic factors were determined by multivariate linear regression after adjusting potential confounders using generalized estimating equations (GEE). The mean global p-RNFL thickness was 106.60 ± 9.41 μm (range: 72 to 171 μm) in the right eyes, 105.99 ± 9.30 μm (range: 76 to 163 μm) in the left eyes, and 106.29 ± 9.36 μm (range: 72 to 171 μm) across both eyes. Age was positively correlated with p-RNFL after adjusting for axial length (AL) and confounding factors (β = 0.509; p = 0.001). Upon multivariable analysis, AL was positively associated with temporal p-RNFL thickness (β = 3.186, p < 0.001) but negatively with non-temporal p-RNFL thickness (β = (10.003, −2.294), p < 0.001). Sectoral p-RNFL was the thickest in the inferior temporal region (155.12 ± 19.42 μm, range 68 to 271 μm), followed by the superior temporal region (154.67 ± 19.99 μm, range 32 to 177 μm). To conclude, p-RNFL increased significantly with older age among children 6 to 8 years old in a converse trend compared to adults. Our results provide a reference for interpreting OCT information in children and suggest that stable p-RNFL thickness may not indicate a stable disease status in pediatric patients due to the age effects. MDPI 2022-02-15 /pmc/articles/PMC8870939/ /pubmed/35204590 http://dx.doi.org/10.3390/diagnostics12020500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Xiu-Juan
Lau, Yi-Han
Wang, Yu-Meng
Chan, Hei-Nga
Chan, Poemen P.
Kam, Ka-Wai
Ip, Patrick
Zhang, Wei
Young, Alvin L.
Tham, Clement C.
Pang, Chi-Pui
Chen, Li-Jia
Yam, Jason C.
Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title_full Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title_fullStr Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title_full_unstemmed Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title_short Thicker Retinal Nerve Fiber Layer with Age among Schoolchildren: The Hong Kong Children Eye Study
title_sort thicker retinal nerve fiber layer with age among schoolchildren: the hong kong children eye study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870939/
https://www.ncbi.nlm.nih.gov/pubmed/35204590
http://dx.doi.org/10.3390/diagnostics12020500
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