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Surgical Site Cytology to Diagnose Spinal Lesions

Patients with new-onset malignant spinal lesions often have an urgent need for local spine intervention and systemic therapy. For optimal management, it is crucial to diagnose the underlying disease as quickly and reliably as possible. The aim of our current study was to determine the feasibility, s...

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Autores principales: Koepke, Leon-Gordian, Heuer, Annika, Stangenberg, Martin, Dreimann, Marc, Welker, Lutz, Bokemeyer, Carsten, Strahl, André, Asemissen, Anne Marie, Viezens, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871040/
https://www.ncbi.nlm.nih.gov/pubmed/35204401
http://dx.doi.org/10.3390/diagnostics12020310
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author Koepke, Leon-Gordian
Heuer, Annika
Stangenberg, Martin
Dreimann, Marc
Welker, Lutz
Bokemeyer, Carsten
Strahl, André
Asemissen, Anne Marie
Viezens, Lennart
author_facet Koepke, Leon-Gordian
Heuer, Annika
Stangenberg, Martin
Dreimann, Marc
Welker, Lutz
Bokemeyer, Carsten
Strahl, André
Asemissen, Anne Marie
Viezens, Lennart
author_sort Koepke, Leon-Gordian
collection PubMed
description Patients with new-onset malignant spinal lesions often have an urgent need for local spine intervention and systemic therapy. For optimal management, it is crucial to diagnose the underlying disease as quickly and reliably as possible. The aim of our current study was to determine the feasibility, sensitivity, specificity, and diagnostic certainty of complementary cytological evaluation of spinal lesions suspected of malignancy. In 44 patients, we performed histopathological biopsies and in parallel cytologic preparations from the malignant site. Cytological smears were prepared and stained for May-Grunwald and Giemsa. Bone biopsies were histopathologically analyzed according to the existing standard-of-care practices. In 42 of 44 cases (95%), a cytological sample was successfully obtained. In 40 cases (95.2%, Cohen’s kappa: 0.77), the cytological diagnosis agreed with the histological diagnosis regarding the identification of a malignant lesion. This resulted in a sensitivity of 97% and a specificity of 80% as well as a diagnostic safety of 95%. Cytological analysis in the context of spinal surgery proved sufficient to establish a diagnosis of malignancy or its exclusion, expanding the existing diagnostic spectrum. Furthermore, implementation of this process as a routine clinical diagnostic might shorten the time to diagnosis and improve the treatment of this vulnerable patient group.
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spelling pubmed-88710402022-02-25 Surgical Site Cytology to Diagnose Spinal Lesions Koepke, Leon-Gordian Heuer, Annika Stangenberg, Martin Dreimann, Marc Welker, Lutz Bokemeyer, Carsten Strahl, André Asemissen, Anne Marie Viezens, Lennart Diagnostics (Basel) Article Patients with new-onset malignant spinal lesions often have an urgent need for local spine intervention and systemic therapy. For optimal management, it is crucial to diagnose the underlying disease as quickly and reliably as possible. The aim of our current study was to determine the feasibility, sensitivity, specificity, and diagnostic certainty of complementary cytological evaluation of spinal lesions suspected of malignancy. In 44 patients, we performed histopathological biopsies and in parallel cytologic preparations from the malignant site. Cytological smears were prepared and stained for May-Grunwald and Giemsa. Bone biopsies were histopathologically analyzed according to the existing standard-of-care practices. In 42 of 44 cases (95%), a cytological sample was successfully obtained. In 40 cases (95.2%, Cohen’s kappa: 0.77), the cytological diagnosis agreed with the histological diagnosis regarding the identification of a malignant lesion. This resulted in a sensitivity of 97% and a specificity of 80% as well as a diagnostic safety of 95%. Cytological analysis in the context of spinal surgery proved sufficient to establish a diagnosis of malignancy or its exclusion, expanding the existing diagnostic spectrum. Furthermore, implementation of this process as a routine clinical diagnostic might shorten the time to diagnosis and improve the treatment of this vulnerable patient group. MDPI 2022-01-26 /pmc/articles/PMC8871040/ /pubmed/35204401 http://dx.doi.org/10.3390/diagnostics12020310 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koepke, Leon-Gordian
Heuer, Annika
Stangenberg, Martin
Dreimann, Marc
Welker, Lutz
Bokemeyer, Carsten
Strahl, André
Asemissen, Anne Marie
Viezens, Lennart
Surgical Site Cytology to Diagnose Spinal Lesions
title Surgical Site Cytology to Diagnose Spinal Lesions
title_full Surgical Site Cytology to Diagnose Spinal Lesions
title_fullStr Surgical Site Cytology to Diagnose Spinal Lesions
title_full_unstemmed Surgical Site Cytology to Diagnose Spinal Lesions
title_short Surgical Site Cytology to Diagnose Spinal Lesions
title_sort surgical site cytology to diagnose spinal lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871040/
https://www.ncbi.nlm.nih.gov/pubmed/35204401
http://dx.doi.org/10.3390/diagnostics12020310
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