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Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes

The pandemic raised a discussion about the postponement of medical interventions for non-small cell lung cancer (NSCLC). We analyzed the characteristics of pretreatment diagnostic assessment in the pandemic and the influence of diagnostic assessment on outcomes. A total of 96 patients with stereotac...

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Autores principales: Habermann, Felix-Nikolai Oschinka Jegor, Schmitt, Daniela, Failing, Thomas, Fischer, Jann, Ziegler, David Alexander, Fischer, Laura Anna, Alt, Niklas Josua, Muster, Julian, Donath, Sandra, Hille, Andrea, Schirmer, Markus Anton, Guhlich, Manuel, El Shafie, Rami A., Rieken, Stefan, Leu, Martin, Dröge, Leif Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871078/
https://www.ncbi.nlm.nih.gov/pubmed/35200591
http://dx.doi.org/10.3390/curroncol29020092
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author Habermann, Felix-Nikolai Oschinka Jegor
Schmitt, Daniela
Failing, Thomas
Fischer, Jann
Ziegler, David Alexander
Fischer, Laura Anna
Alt, Niklas Josua
Muster, Julian
Donath, Sandra
Hille, Andrea
Schirmer, Markus Anton
Guhlich, Manuel
El Shafie, Rami A.
Rieken, Stefan
Leu, Martin
Dröge, Leif Hendrik
author_facet Habermann, Felix-Nikolai Oschinka Jegor
Schmitt, Daniela
Failing, Thomas
Fischer, Jann
Ziegler, David Alexander
Fischer, Laura Anna
Alt, Niklas Josua
Muster, Julian
Donath, Sandra
Hille, Andrea
Schirmer, Markus Anton
Guhlich, Manuel
El Shafie, Rami A.
Rieken, Stefan
Leu, Martin
Dröge, Leif Hendrik
author_sort Habermann, Felix-Nikolai Oschinka Jegor
collection PubMed
description The pandemic raised a discussion about the postponement of medical interventions for non-small cell lung cancer (NSCLC). We analyzed the characteristics of pretreatment diagnostic assessment in the pandemic and the influence of diagnostic assessment on outcomes. A total of 96 patients with stereotactic body radiation therapy (SBRT) for NSCLC were included. The number of patients increased from mean 0.9 (2012–2019) to 1.45 per month in the COVID era (p < 0.05). Pandemic-related factors (contact reduction, limited intensive care unit resources) might have influenced clinical decision making towards SBRT. The time from pretreatment assessment (multidisciplinary tumor board decision, bronchoscopy, planning CT) to SBRT was longer during the COVID period (p < 0.05). Reduced services, staff shortage, or appointment management to mitigate infection risks might explain this finding. Overall survival, progression-free survival, locoregional progression-free survival, and distant progression-free survival were superior in patients who received a PET/CT scan prior to SBRT (p < 0.05). This supports that SBRT guidelines advocate the acquisition of a PET/CT scan. A longer time from PET/CT scan/conventional staging to SBRT (<10 vs. ≥10 weeks) was associated with worse locoregional control (p < 0.05). The postponement of diagnostic or therapeutic measures in the pandemic should be discussed cautiously. Patient- and tumor-related features should be evaluated in detail.
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spelling pubmed-88710782022-02-25 Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes Habermann, Felix-Nikolai Oschinka Jegor Schmitt, Daniela Failing, Thomas Fischer, Jann Ziegler, David Alexander Fischer, Laura Anna Alt, Niklas Josua Muster, Julian Donath, Sandra Hille, Andrea Schirmer, Markus Anton Guhlich, Manuel El Shafie, Rami A. Rieken, Stefan Leu, Martin Dröge, Leif Hendrik Curr Oncol Article The pandemic raised a discussion about the postponement of medical interventions for non-small cell lung cancer (NSCLC). We analyzed the characteristics of pretreatment diagnostic assessment in the pandemic and the influence of diagnostic assessment on outcomes. A total of 96 patients with stereotactic body radiation therapy (SBRT) for NSCLC were included. The number of patients increased from mean 0.9 (2012–2019) to 1.45 per month in the COVID era (p < 0.05). Pandemic-related factors (contact reduction, limited intensive care unit resources) might have influenced clinical decision making towards SBRT. The time from pretreatment assessment (multidisciplinary tumor board decision, bronchoscopy, planning CT) to SBRT was longer during the COVID period (p < 0.05). Reduced services, staff shortage, or appointment management to mitigate infection risks might explain this finding. Overall survival, progression-free survival, locoregional progression-free survival, and distant progression-free survival were superior in patients who received a PET/CT scan prior to SBRT (p < 0.05). This supports that SBRT guidelines advocate the acquisition of a PET/CT scan. A longer time from PET/CT scan/conventional staging to SBRT (<10 vs. ≥10 weeks) was associated with worse locoregional control (p < 0.05). The postponement of diagnostic or therapeutic measures in the pandemic should be discussed cautiously. Patient- and tumor-related features should be evaluated in detail. MDPI 2022-02-13 /pmc/articles/PMC8871078/ /pubmed/35200591 http://dx.doi.org/10.3390/curroncol29020092 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Habermann, Felix-Nikolai Oschinka Jegor
Schmitt, Daniela
Failing, Thomas
Fischer, Jann
Ziegler, David Alexander
Fischer, Laura Anna
Alt, Niklas Josua
Muster, Julian
Donath, Sandra
Hille, Andrea
Schirmer, Markus Anton
Guhlich, Manuel
El Shafie, Rami A.
Rieken, Stefan
Leu, Martin
Dröge, Leif Hendrik
Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title_full Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title_fullStr Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title_full_unstemmed Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title_short Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes
title_sort patterns of pretreatment diagnostic assessment in patients treated with stereotactic body radiation therapy (sbrt) for non-small cell lung cancer (nsclc): special characteristics in the covid pandemic and influence on outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871078/
https://www.ncbi.nlm.nih.gov/pubmed/35200591
http://dx.doi.org/10.3390/curroncol29020092
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