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Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cell...

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Autores principales: Angelico, Giuseppe, Marletta, Stefano, Broggi, Giuseppe, Vigneri, Paolo, Vecchio, Giada Maria, Salvatorelli, Lucia, Magro, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871080/
https://www.ncbi.nlm.nih.gov/pubmed/35204448
http://dx.doi.org/10.3390/diagnostics12020357
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author Angelico, Giuseppe
Marletta, Stefano
Broggi, Giuseppe
Vigneri, Paolo
Vecchio, Giada Maria
Salvatorelli, Lucia
Magro, Gaetano
author_facet Angelico, Giuseppe
Marletta, Stefano
Broggi, Giuseppe
Vigneri, Paolo
Vecchio, Giada Maria
Salvatorelli, Lucia
Magro, Gaetano
author_sort Angelico, Giuseppe
collection PubMed
description Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cellular angiofibroma (CAF), angiomyofibroblastoma (AMFB) or myofibroblastoma (MFB). Despite the differential diagnosis between these entities being usually straightforward, their increasingly recognized unusual morphological variants, along with the overlapping morphological and immunohistochemical features among these tumours, may raise serious differential diagnostic problems. Methods and Results: The data presented in the present paper have been retrieved from the entire published literature on the PubMed website about DAM, CAF, AFMB and MFB from 1984 to 2021. The selected articles are mainly represented by small-series, and, more rarely, single-case reports with unusual clinicopathologic features. The present review focuses on the diagnostic clues of the stromal tumours of the lower female genital tract to achieve a correct classification. The main clinicopathologic features of each single entity, emphasizing their differential diagnostic clues, are discussed and summarized in tables. Representative illustrations, including the unusual morphological variants, of each single tumour are also provided. Conclusion: Awareness by pathologists of the wide morphological and immunohistochemical spectrum exhibited by these tumours is crucial to achieve correct diagnoses and to avoid confusion with reactive conditions or other benign or malignant entities.
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spelling pubmed-88710802022-02-25 Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview Angelico, Giuseppe Marletta, Stefano Broggi, Giuseppe Vigneri, Paolo Vecchio, Giada Maria Salvatorelli, Lucia Magro, Gaetano Diagnostics (Basel) Review Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cellular angiofibroma (CAF), angiomyofibroblastoma (AMFB) or myofibroblastoma (MFB). Despite the differential diagnosis between these entities being usually straightforward, their increasingly recognized unusual morphological variants, along with the overlapping morphological and immunohistochemical features among these tumours, may raise serious differential diagnostic problems. Methods and Results: The data presented in the present paper have been retrieved from the entire published literature on the PubMed website about DAM, CAF, AFMB and MFB from 1984 to 2021. The selected articles are mainly represented by small-series, and, more rarely, single-case reports with unusual clinicopathologic features. The present review focuses on the diagnostic clues of the stromal tumours of the lower female genital tract to achieve a correct classification. The main clinicopathologic features of each single entity, emphasizing their differential diagnostic clues, are discussed and summarized in tables. Representative illustrations, including the unusual morphological variants, of each single tumour are also provided. Conclusion: Awareness by pathologists of the wide morphological and immunohistochemical spectrum exhibited by these tumours is crucial to achieve correct diagnoses and to avoid confusion with reactive conditions or other benign or malignant entities. MDPI 2022-01-31 /pmc/articles/PMC8871080/ /pubmed/35204448 http://dx.doi.org/10.3390/diagnostics12020357 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Angelico, Giuseppe
Marletta, Stefano
Broggi, Giuseppe
Vigneri, Paolo
Vecchio, Giada Maria
Salvatorelli, Lucia
Magro, Gaetano
Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title_full Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title_fullStr Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title_full_unstemmed Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title_short Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview
title_sort practical approach to the diagnosis of the vulvo-vaginal stromal tumors: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871080/
https://www.ncbi.nlm.nih.gov/pubmed/35204448
http://dx.doi.org/10.3390/diagnostics12020357
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