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The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)

Multiple System Atrophy—Parkinsonism Predominant (MSA-P) and Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) are the clinical manifestations of atypical parkinsonism. Currently, there are no efficient in vivo methods available relating to neuroimaging or biochemical analysis in the e...

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Autores principales: Alster, Piotr, Nieciecki, Michał, Migda, Bartosz, Kutyłowski, Michał, Madetko, Natalia, Duszyńska-Wąs, Karolina, Charzyńska, Ingeborga, Koziorowski, Dariusz, Królicki, Leszek, Friedman, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871165/
https://www.ncbi.nlm.nih.gov/pubmed/35204476
http://dx.doi.org/10.3390/diagnostics12020385
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author Alster, Piotr
Nieciecki, Michał
Migda, Bartosz
Kutyłowski, Michał
Madetko, Natalia
Duszyńska-Wąs, Karolina
Charzyńska, Ingeborga
Koziorowski, Dariusz
Królicki, Leszek
Friedman, Andrzej
author_facet Alster, Piotr
Nieciecki, Michał
Migda, Bartosz
Kutyłowski, Michał
Madetko, Natalia
Duszyńska-Wąs, Karolina
Charzyńska, Ingeborga
Koziorowski, Dariusz
Królicki, Leszek
Friedman, Andrzej
author_sort Alster, Piotr
collection PubMed
description Multiple System Atrophy—Parkinsonism Predominant (MSA-P) and Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) are the clinical manifestations of atypical parkinsonism. Currently, there are no efficient in vivo methods available relating to neuroimaging or biochemical analysis in the examination of these entities. Among the advanced methods available, using positron emission tomography is constrained by high cost and low accessibility. In this study the authors examined patients with two types of atypical parkinsonism—MSA-P and PSP-P, which are difficult to differentiate, especially in the early years of their development. The aim of this study was to assess whether the examination of patients in the period following the early years (3–6-year duration of symptoms) could be enhanced by perfusion single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) or evaluation of cognitive abilities. Extended examination using MRI and perfusion SPECT showed that the evaluation of the mesencephalon/pons ratio, mesencephalic volume decrease, the Magnetic Resonance Parkinsonism Index (MRPI) and frontal perfusion should be considered more feasible than screening cognitive evaluation in MSA-P and PSP-P with a 3–6-year duration of symptoms.
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spelling pubmed-88711652022-02-25 The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT) Alster, Piotr Nieciecki, Michał Migda, Bartosz Kutyłowski, Michał Madetko, Natalia Duszyńska-Wąs, Karolina Charzyńska, Ingeborga Koziorowski, Dariusz Królicki, Leszek Friedman, Andrzej Diagnostics (Basel) Article Multiple System Atrophy—Parkinsonism Predominant (MSA-P) and Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) are the clinical manifestations of atypical parkinsonism. Currently, there are no efficient in vivo methods available relating to neuroimaging or biochemical analysis in the examination of these entities. Among the advanced methods available, using positron emission tomography is constrained by high cost and low accessibility. In this study the authors examined patients with two types of atypical parkinsonism—MSA-P and PSP-P, which are difficult to differentiate, especially in the early years of their development. The aim of this study was to assess whether the examination of patients in the period following the early years (3–6-year duration of symptoms) could be enhanced by perfusion single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) or evaluation of cognitive abilities. Extended examination using MRI and perfusion SPECT showed that the evaluation of the mesencephalon/pons ratio, mesencephalic volume decrease, the Magnetic Resonance Parkinsonism Index (MRPI) and frontal perfusion should be considered more feasible than screening cognitive evaluation in MSA-P and PSP-P with a 3–6-year duration of symptoms. MDPI 2022-02-02 /pmc/articles/PMC8871165/ /pubmed/35204476 http://dx.doi.org/10.3390/diagnostics12020385 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alster, Piotr
Nieciecki, Michał
Migda, Bartosz
Kutyłowski, Michał
Madetko, Natalia
Duszyńska-Wąs, Karolina
Charzyńska, Ingeborga
Koziorowski, Dariusz
Królicki, Leszek
Friedman, Andrzej
The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title_full The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title_fullStr The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title_full_unstemmed The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title_short The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy—Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT)
title_sort strengths and obstacles in the differential diagnosis of progressive supranuclear palsy—parkinsonism predominant (psp-p) and multiple system atrophy (msa) using magnetic resonance imaging (mri) and perfusion single photon emission computed tomography (spect)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871165/
https://www.ncbi.nlm.nih.gov/pubmed/35204476
http://dx.doi.org/10.3390/diagnostics12020385
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