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Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings

Early detection of pancreatic ductal adenocarcinoma (PDAC) in the general population is difficult due to unknown clinical characteristics. This study was conducted to clarify the factors associated with early stage PDAC. Well-known symptoms and factors associated with PDAC were classified into clini...

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Autores principales: Sagami, Ryota, Sato, Takao, Mizukami, Kazuhiro, Motomura, Mitsuteru, Okamoto, Kazuhisa, Fukuchi, Satoshi, Otsuka, Yuichiro, Abe, Takashi, Ono, Hideki, Mori, Kei, Wada, Kurato, Iwaki, Tomoyuki, Nishikiori, Hidefumi, Honda, Koichi, Amano, Yuji, Murakami, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871200/
https://www.ncbi.nlm.nih.gov/pubmed/35204468
http://dx.doi.org/10.3390/diagnostics12020377
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author Sagami, Ryota
Sato, Takao
Mizukami, Kazuhiro
Motomura, Mitsuteru
Okamoto, Kazuhisa
Fukuchi, Satoshi
Otsuka, Yuichiro
Abe, Takashi
Ono, Hideki
Mori, Kei
Wada, Kurato
Iwaki, Tomoyuki
Nishikiori, Hidefumi
Honda, Koichi
Amano, Yuji
Murakami, Kazunari
author_facet Sagami, Ryota
Sato, Takao
Mizukami, Kazuhiro
Motomura, Mitsuteru
Okamoto, Kazuhisa
Fukuchi, Satoshi
Otsuka, Yuichiro
Abe, Takashi
Ono, Hideki
Mori, Kei
Wada, Kurato
Iwaki, Tomoyuki
Nishikiori, Hidefumi
Honda, Koichi
Amano, Yuji
Murakami, Kazunari
author_sort Sagami, Ryota
collection PubMed
description Early detection of pancreatic ductal adenocarcinoma (PDAC) in the general population is difficult due to unknown clinical characteristics. This study was conducted to clarify the factors associated with early stage PDAC. Well-known symptoms and factors associated with PDAC were classified into clinical indicators, risk factors, and imaging findings concomitant with early stage PDAC. To analyze these factors for the detection of patients with early stage PDAC compared to patients without PDAC, we constructed new diagnostic strategies. The factors of 35 patients with early stage PDAC (stage 0 and IA) and 801 patients without PDAC were compared retrospectively. Clinical indicators; presence and number of indicators, elevated pancreatic enzyme level, tumor biomarker level, acute pancreatitis history, risk factors; familial pancreatic cancer, diabetes mellitus, smoking history, imaging findings; presence and number of findings, and main pancreatic duct dilation were significant factors for early stage PDAC detection. A new screening strategy to select patients who should be examined by imaging modalities from evaluating clinical indicators and risk factors and approaching a definitive diagnosis by evaluating imaging findings had a relatively high sensitivity, specificity, and areas under the curve of 80.0%, 80.8%, and 0.80, respectively. Diagnosis based on the new category and strategy may be reasonable for early stage PDAC detection.
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spelling pubmed-88712002022-02-25 Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings Sagami, Ryota Sato, Takao Mizukami, Kazuhiro Motomura, Mitsuteru Okamoto, Kazuhisa Fukuchi, Satoshi Otsuka, Yuichiro Abe, Takashi Ono, Hideki Mori, Kei Wada, Kurato Iwaki, Tomoyuki Nishikiori, Hidefumi Honda, Koichi Amano, Yuji Murakami, Kazunari Diagnostics (Basel) Article Early detection of pancreatic ductal adenocarcinoma (PDAC) in the general population is difficult due to unknown clinical characteristics. This study was conducted to clarify the factors associated with early stage PDAC. Well-known symptoms and factors associated with PDAC were classified into clinical indicators, risk factors, and imaging findings concomitant with early stage PDAC. To analyze these factors for the detection of patients with early stage PDAC compared to patients without PDAC, we constructed new diagnostic strategies. The factors of 35 patients with early stage PDAC (stage 0 and IA) and 801 patients without PDAC were compared retrospectively. Clinical indicators; presence and number of indicators, elevated pancreatic enzyme level, tumor biomarker level, acute pancreatitis history, risk factors; familial pancreatic cancer, diabetes mellitus, smoking history, imaging findings; presence and number of findings, and main pancreatic duct dilation were significant factors for early stage PDAC detection. A new screening strategy to select patients who should be examined by imaging modalities from evaluating clinical indicators and risk factors and approaching a definitive diagnosis by evaluating imaging findings had a relatively high sensitivity, specificity, and areas under the curve of 80.0%, 80.8%, and 0.80, respectively. Diagnosis based on the new category and strategy may be reasonable for early stage PDAC detection. MDPI 2022-02-01 /pmc/articles/PMC8871200/ /pubmed/35204468 http://dx.doi.org/10.3390/diagnostics12020377 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sagami, Ryota
Sato, Takao
Mizukami, Kazuhiro
Motomura, Mitsuteru
Okamoto, Kazuhisa
Fukuchi, Satoshi
Otsuka, Yuichiro
Abe, Takashi
Ono, Hideki
Mori, Kei
Wada, Kurato
Iwaki, Tomoyuki
Nishikiori, Hidefumi
Honda, Koichi
Amano, Yuji
Murakami, Kazunari
Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title_full Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title_fullStr Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title_full_unstemmed Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title_short Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
title_sort diagnostic strategy of early stage pancreatic cancer via clinical predictor assessment: clinical indicators, risk factors and imaging findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871200/
https://www.ncbi.nlm.nih.gov/pubmed/35204468
http://dx.doi.org/10.3390/diagnostics12020377
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