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Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sT...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871337/ https://www.ncbi.nlm.nih.gov/pubmed/35204613 http://dx.doi.org/10.3390/diagnostics12020524 |
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author | Tornyigah, Bernard Blankson, Samuel Odarkwei Adamou, Rafiou Moussiliou, Azizath Rietmeyer, Lauriane Tettey, Patrick Dikroh, Liliane Addo, Bernard Lamptey, Helena Alao, Maroufou J. Amoussou, Annick Padounou, Caroline Roussilhon, Christian Pons, Sylvie Mensah, Benedicta Ayiedu Ndam, Nicaise Tuikue Tahar, Rachida |
author_facet | Tornyigah, Bernard Blankson, Samuel Odarkwei Adamou, Rafiou Moussiliou, Azizath Rietmeyer, Lauriane Tettey, Patrick Dikroh, Liliane Addo, Bernard Lamptey, Helena Alao, Maroufou J. Amoussou, Annick Padounou, Caroline Roussilhon, Christian Pons, Sylvie Mensah, Benedicta Ayiedu Ndam, Nicaise Tuikue Tahar, Rachida |
author_sort | Tornyigah, Bernard |
collection | PubMed |
description | Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases. |
format | Online Article Text |
id | pubmed-8871337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88713372022-02-25 Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria Tornyigah, Bernard Blankson, Samuel Odarkwei Adamou, Rafiou Moussiliou, Azizath Rietmeyer, Lauriane Tettey, Patrick Dikroh, Liliane Addo, Bernard Lamptey, Helena Alao, Maroufou J. Amoussou, Annick Padounou, Caroline Roussilhon, Christian Pons, Sylvie Mensah, Benedicta Ayiedu Ndam, Nicaise Tuikue Tahar, Rachida Diagnostics (Basel) Article Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases. MDPI 2022-02-18 /pmc/articles/PMC8871337/ /pubmed/35204613 http://dx.doi.org/10.3390/diagnostics12020524 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tornyigah, Bernard Blankson, Samuel Odarkwei Adamou, Rafiou Moussiliou, Azizath Rietmeyer, Lauriane Tettey, Patrick Dikroh, Liliane Addo, Bernard Lamptey, Helena Alao, Maroufou J. Amoussou, Annick Padounou, Caroline Roussilhon, Christian Pons, Sylvie Mensah, Benedicta Ayiedu Ndam, Nicaise Tuikue Tahar, Rachida Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title_full | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title_fullStr | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title_full_unstemmed | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title_short | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
title_sort | specific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in beninese children with plasmodium falciparum malaria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871337/ https://www.ncbi.nlm.nih.gov/pubmed/35204613 http://dx.doi.org/10.3390/diagnostics12020524 |
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