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Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria

Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sT...

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Autores principales: Tornyigah, Bernard, Blankson, Samuel Odarkwei, Adamou, Rafiou, Moussiliou, Azizath, Rietmeyer, Lauriane, Tettey, Patrick, Dikroh, Liliane, Addo, Bernard, Lamptey, Helena, Alao, Maroufou J., Amoussou, Annick, Padounou, Caroline, Roussilhon, Christian, Pons, Sylvie, Mensah, Benedicta Ayiedu, Ndam, Nicaise Tuikue, Tahar, Rachida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871337/
https://www.ncbi.nlm.nih.gov/pubmed/35204613
http://dx.doi.org/10.3390/diagnostics12020524
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author Tornyigah, Bernard
Blankson, Samuel Odarkwei
Adamou, Rafiou
Moussiliou, Azizath
Rietmeyer, Lauriane
Tettey, Patrick
Dikroh, Liliane
Addo, Bernard
Lamptey, Helena
Alao, Maroufou J.
Amoussou, Annick
Padounou, Caroline
Roussilhon, Christian
Pons, Sylvie
Mensah, Benedicta Ayiedu
Ndam, Nicaise Tuikue
Tahar, Rachida
author_facet Tornyigah, Bernard
Blankson, Samuel Odarkwei
Adamou, Rafiou
Moussiliou, Azizath
Rietmeyer, Lauriane
Tettey, Patrick
Dikroh, Liliane
Addo, Bernard
Lamptey, Helena
Alao, Maroufou J.
Amoussou, Annick
Padounou, Caroline
Roussilhon, Christian
Pons, Sylvie
Mensah, Benedicta Ayiedu
Ndam, Nicaise Tuikue
Tahar, Rachida
author_sort Tornyigah, Bernard
collection PubMed
description Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.
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spelling pubmed-88713372022-02-25 Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria Tornyigah, Bernard Blankson, Samuel Odarkwei Adamou, Rafiou Moussiliou, Azizath Rietmeyer, Lauriane Tettey, Patrick Dikroh, Liliane Addo, Bernard Lamptey, Helena Alao, Maroufou J. Amoussou, Annick Padounou, Caroline Roussilhon, Christian Pons, Sylvie Mensah, Benedicta Ayiedu Ndam, Nicaise Tuikue Tahar, Rachida Diagnostics (Basel) Article Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases. MDPI 2022-02-18 /pmc/articles/PMC8871337/ /pubmed/35204613 http://dx.doi.org/10.3390/diagnostics12020524 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tornyigah, Bernard
Blankson, Samuel Odarkwei
Adamou, Rafiou
Moussiliou, Azizath
Rietmeyer, Lauriane
Tettey, Patrick
Dikroh, Liliane
Addo, Bernard
Lamptey, Helena
Alao, Maroufou J.
Amoussou, Annick
Padounou, Caroline
Roussilhon, Christian
Pons, Sylvie
Mensah, Benedicta Ayiedu
Ndam, Nicaise Tuikue
Tahar, Rachida
Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title_full Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title_fullStr Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title_full_unstemmed Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title_short Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
title_sort specific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in beninese children with plasmodium falciparum malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871337/
https://www.ncbi.nlm.nih.gov/pubmed/35204613
http://dx.doi.org/10.3390/diagnostics12020524
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