Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition

Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels involved in fast synaptic transmission. Pharmacological inhibition of ASIC1a reduces neurotoxicity and stroke infarct volumes, with the cysteine knot toxin psalmotoxin-1 (PcTx1) being one of the most potent and selective inh...

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Detalles Bibliográficos
Autores principales: Heusser, Stephanie A, Borg, Christian B, Colding, Janne M, Pless, Stephan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871370/
https://www.ncbi.nlm.nih.gov/pubmed/35156612
http://dx.doi.org/10.7554/eLife.73384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871370/
https://www.ncbi.nlm.nih.gov/pubmed/35156612
http://dx.doi.org/10.7554/eLife.73384

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