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Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life

Left atrial strain (LAS) is the most promising technique for assessment of diastolic dysfunction but few data are available in neonates. Our aim was to assess feasibility and reproducibility, and to provide reference ranges of LAS in healthy neonates in the first 48 h of life. We performed one echoc...

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Autores principales: Ficial, Benjamim, Corsini, Iuri, Clemente, Maria, Cappelleri, Alessia, Remaschi, Giulia, Quer, Laura, Urbani, Giulia, Sandrini, Camilla, Biban, Paolo, Dani, Carlo, Benfari, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871374/
https://www.ncbi.nlm.nih.gov/pubmed/35204441
http://dx.doi.org/10.3390/diagnostics12020350
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author Ficial, Benjamim
Corsini, Iuri
Clemente, Maria
Cappelleri, Alessia
Remaschi, Giulia
Quer, Laura
Urbani, Giulia
Sandrini, Camilla
Biban, Paolo
Dani, Carlo
Benfari, Giovanni
author_facet Ficial, Benjamim
Corsini, Iuri
Clemente, Maria
Cappelleri, Alessia
Remaschi, Giulia
Quer, Laura
Urbani, Giulia
Sandrini, Camilla
Biban, Paolo
Dani, Carlo
Benfari, Giovanni
author_sort Ficial, Benjamim
collection PubMed
description Left atrial strain (LAS) is the most promising technique for assessment of diastolic dysfunction but few data are available in neonates. Our aim was to assess feasibility and reproducibility, and to provide reference ranges of LAS in healthy neonates in the first 48 h of life. We performed one echocardiography in 30 neonates to assess feasibility and develop a standard protocol for image acquisition and analysis. LAS reservoir (LASr), conduit (LAScd) and contraction (LASct) were measured. We performed echocardiography at 24 and 48 h of life in an unrelated cohort of 90 neonates. Median (range) gestational age and weight of the first cohort were 34.4 (26.4–40.2) weeks and 2075 (660–3680) g. LAS feasibility was 96.7%. Mean (SD) gestational age and weight of the second cohort were 34.2 (3.8) weeks and 2162 (833) g. Mean (SD) LASr significantly increased from 24 to 48 h: 32.9 (3.2) to 36.8 (4.6). Mean (SD) LAScd and LASct were stable: −20.6 (8.0) and −20.8 (9.9), −11.6 (4.9) and −13.5 (6.4). Intra and interobserver intraclass correlation coefficient for LASr, LAScd and LASct were 0.992, 0.993, 0.986 and 0.936, 0.938 and 0.871, respectively. We showed high feasibility and reproducibility of LAS in neonates and provided reference ranges.
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spelling pubmed-88713742022-02-25 Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life Ficial, Benjamim Corsini, Iuri Clemente, Maria Cappelleri, Alessia Remaschi, Giulia Quer, Laura Urbani, Giulia Sandrini, Camilla Biban, Paolo Dani, Carlo Benfari, Giovanni Diagnostics (Basel) Article Left atrial strain (LAS) is the most promising technique for assessment of diastolic dysfunction but few data are available in neonates. Our aim was to assess feasibility and reproducibility, and to provide reference ranges of LAS in healthy neonates in the first 48 h of life. We performed one echocardiography in 30 neonates to assess feasibility and develop a standard protocol for image acquisition and analysis. LAS reservoir (LASr), conduit (LAScd) and contraction (LASct) were measured. We performed echocardiography at 24 and 48 h of life in an unrelated cohort of 90 neonates. Median (range) gestational age and weight of the first cohort were 34.4 (26.4–40.2) weeks and 2075 (660–3680) g. LAS feasibility was 96.7%. Mean (SD) gestational age and weight of the second cohort were 34.2 (3.8) weeks and 2162 (833) g. Mean (SD) LASr significantly increased from 24 to 48 h: 32.9 (3.2) to 36.8 (4.6). Mean (SD) LAScd and LASct were stable: −20.6 (8.0) and −20.8 (9.9), −11.6 (4.9) and −13.5 (6.4). Intra and interobserver intraclass correlation coefficient for LASr, LAScd and LASct were 0.992, 0.993, 0.986 and 0.936, 0.938 and 0.871, respectively. We showed high feasibility and reproducibility of LAS in neonates and provided reference ranges. MDPI 2022-01-29 /pmc/articles/PMC8871374/ /pubmed/35204441 http://dx.doi.org/10.3390/diagnostics12020350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ficial, Benjamim
Corsini, Iuri
Clemente, Maria
Cappelleri, Alessia
Remaschi, Giulia
Quer, Laura
Urbani, Giulia
Sandrini, Camilla
Biban, Paolo
Dani, Carlo
Benfari, Giovanni
Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title_full Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title_fullStr Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title_full_unstemmed Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title_short Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life
title_sort feasibility, reproducibility and reference ranges of left atrial strain in preterm and term neonates in the first 48 h of life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871374/
https://www.ncbi.nlm.nih.gov/pubmed/35204441
http://dx.doi.org/10.3390/diagnostics12020350
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